CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038201
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 3-hydroxy-3-methylglutaryl-coenzyme A reductase 
Protein Synonyms/Alias
  
Gene Name
 Hmgcr 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
142SRASALAKFALSSNSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 210 AA 
Protein Sequence
MLSRLFRMHG LFVASHPWEV IVGTVTLTIC MMSMNMFTGN NKICGWNYEC PKFEEDVLSS 60
DIIILTITRC IAILYIYFQF QNLRQLGSKY ILGIAGLFTI FSSFVFSTVV IHFLDKELTG 120
LNEALPFFLL LIDLSRASAL AKFALSSNSQ DEVRENIARG MAILGPTFTL DALVECLVIG 180
VGTMSGVRQL EIMCCFGCMS VLANYFVFMT 210 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005778; C:peroxisomal membrane; IEA:Compara.
 GO:0004420; F:hydroxymethylglutaryl-CoA reductase (NADPH) activity; IDA:MGI.
 GO:0042282; F:hydroxymethylglutaryl-CoA reductase activity; IEA:Compara.
 GO:0070402; F:NADPH binding; IEA:Compara.
 GO:0007568; P:aging; IEA:Compara.
 GO:0006695; P:cholesterol biosynthetic process; IDA:MGI.
 GO:0015936; P:coenzyme A metabolic process; IEA:InterPro.
 GO:0009790; P:embryo development; IMP:MGI.
 GO:0008299; P:isoprenoid biosynthetic process; IEA:Compara.
 GO:0045445; P:myoblast differentiation; IEA:Compara.
 GO:0061179; P:negative regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Compara.
 GO:0043407; P:negative regulation of MAP kinase activity; IGI:MGI.
 GO:0010664; P:negative regulation of striated muscle cell apoptotic process; IEA:Compara.
 GO:0045908; P:negative regulation of vasodilation; IEA:Compara.
 GO:0061045; P:negative regulation of wound healing; IEA:Compara.
 GO:0010666; P:positive regulation of cardiac muscle cell apoptotic process; IEA:Compara.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Compara.
 GO:0048643; P:positive regulation of skeletal muscle tissue development; IEA:Compara.
 GO:0048661; P:positive regulation of smooth muscle cell proliferation; IEA:Compara.
 GO:0032874; P:positive regulation of stress-activated MAPK cascade; IEA:Compara.
 GO:0051262; P:protein tetramerization; IEA:Compara.
 GO:0045471; P:response to ethanol; IEA:Compara.
 GO:0007584; P:response to nutrient; IEA:Compara.
 GO:0006743; P:ubiquinone metabolic process; IEA:Compara.
 GO:0008542; P:visual learning; IGI:MGI. 
Interpro
 IPR002202; HMG_CoA_Rdtase.
 IPR000731; SSD. 
Pfam
  
SMART
  
PROSITE
 PS50156; SSD 
PRINTS