CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022966
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 GPN-loop GTPase 3 
Protein Synonyms/Alias
 ATP-binding domain 1 family member C 
Gene Name
 GPN3 
Gene Synonyms/Alias
 ATPBD1C; AD-009; UNQ1876/PRO4319 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
16MGPAGSGKSTYCATMubiquitination[1]
181TKMDLLSKKAKKEIEubiquitination[1]
189KAKKEIEKFLDPDMYubiquitination[2]
213LRSKKFKKLTKAICGubiquitination[1]
216KKFKKLTKAICGLIDubiquitination[1, 3, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
 Xu G, Paige JS, Jaffrey SR.
 Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
 NP_BIND 10 17 GTP (Potential).  
Keyword
 Alternative splicing; Complete proteome; GTP-binding; Nucleotide-binding; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 284 AA 
Protein Sequence
MPRYAQLVMG PAGSGKSTYC ATMVQHCEAL NRSVQVVNLD PAAEHFNYSV MADIRELIEV 60
DDVMEDDSLR FGPNGGLVFC MEYFANNFDW LENCLGHVED DYILFDCPGQ IELYTHLPVM 120
KQLVQQLEQW EFRVCGVFLV DSQFMVESFK FISGILAALS AMISLEIPQV NIMTKMDLLS 180
KKAKKEIEKF LDPDMYSLLE DSTSDLRSKK FKKLTKAICG LIDDYSMVRF LPYDQSDEES 240
MNIVLQHIDF AIQYGEDLEF KEPKEREDES SSMFDEYFQE CQDE 284 
Gene Ontology
 GO:0043234; C:protein complex; IDA:LIFEdb.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW. 
Interpro
 IPR027417; P-loop_NTPase.
 IPR004130; Uncharacterised_ATP-bd. 
Pfam
 PF03029; ATP_bind_1 
SMART
  
PROSITE
  
PRINTS