CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036677
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Nucleophosmin 
Protein Synonyms/Alias
  
Gene Name
 NPM1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
24YLFDYHFKVDNDENEacetylation[1, 2, 3]
24YLFDYHFKVDNDENEubiquitination[4]
46VSLGAGAKDELHIVEubiquitination[5]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 59 AA 
Protein Sequence
MEDSMDMDMS PLRPQNYLFD YHFKVDNDEN EHQLSLRTVS LGAGAKDELH IVEAEAMNY 59 
Gene Ontology
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR004301; Nucleoplasmin.
 IPR024057; Nucleoplasmin_core_dom. 
Pfam
  
SMART
  
PROSITE
  
PRINTS