UniProt Accession

 NTAL_HUMAN; Q9GZY6; A6NFK6; A8K209; A8K4F1; D3DXF9; Q9BXX8; Q9NZY9 

Genbank Protein ID

 AF257135; AF045555; AY190023; AF252611; AF252612; AF252613; AF252614; AF161531; AK002099; AK092904; AK290074; AK290916; AC005081; AC005081; CH471200; CH471200; CH471200; CH471200; BC001609; BC009204 

Genbank Nucleotide ID

 AAF91352.1; AAF74978.1; AAO63155.1; AAK37429.1; AAK37430.1; AAK37633.1; AAK37431.1; AAF29018.1; BAA92084.1; BAG52627.1; BAF82763.1; BAF83605.1; AAS07404.1; AAS07405.1; EAW69610.1; EAW69611.1; EAW69612.1; EAW69613.1; AAH01609.1; AAH09204.1 

Protein Name

 Linker for activation of T-cells family member 2 

Protein Synonyms/Alias

 Linker for activation of B-cells; Membrane-associated adapter molecule; Non-T-cell activation linker; Williams-Beuren syndrome chromosomal region 15 protein; Williams-Beuren syndrome chromosomal region 5 protein 

Gene Name

 LAT2 

Gene Synonyms/Alias

 LAB; NTAL; WBS15; WBSCR15; WBSCR5; HSPC046 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
77	ADMAPTRKDKLLQFY	ubiquitination	[1, 2]
79	MAPTRKDKLLQFYPS	ubiquitination	[1, 2, 3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 

Functional Description

 Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2. 

Sequence Annotation

 MOD_RES 40 40 Phosphotyrosine (By similarity).
 MOD_RES 44 44 Phosphoserine.
 MOD_RES 58 58 Phosphotyrosine (By similarity).
 MOD_RES 59 59 Phosphoserine (By similarity).
 MOD_RES 92 92 Phosphoserine (By similarity).
 MOD_RES 95 95 Phosphotyrosine (By similarity).
 MOD_RES 136 136 Phosphotyrosine (Probable).
 MOD_RES 193 193 Phosphotyrosine (Probable).
 MOD_RES 233 233 Phosphotyrosine.
 LIPID 25 25 S-palmitoyl cysteine (Probable).
 LIPID 28 28 S-palmitoyl cysteine (Probable).  

Keyword

 3D-structure; Adaptive immunity; Alternative splicing; Cell membrane; Complete proteome; Immunity; Lipoprotein; Mast cell degranulation; Membrane; Palmitate; Phosphoprotein; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix; Ubl conjugation; Williams-Beuren syndrome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 243 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0045121; C:membrane raft; IDA:HGNC.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0042169; F:SH2 domain binding; IMP:HGNC.
 GO:0042113; P:B cell activation; IDA:HGNC.
 GO:0050853; P:B cell receptor signaling pathway; IDA:HGNC.
 GO:0019722; P:calcium-mediated signaling; IGI:HGNC.
 GO:0043303; P:mast cell degranulation; IEA:UniProtKB-KW. 

Interpro

  

Pfam

  

SMART

  

PROSITE

  

PRINTS