UniProt Accession

 D3Z7F0_MOUSE; D3Z7F0 

Genbank Protein ID

 AC142413 

Genbank Nucleotide ID

  

Protein Name

 L-lactate dehydrogenase 

Protein Synonyms/Alias

  

Gene Name

 Ldhb 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
7	*MATLKEKLIASVAD	ubiquitination	[1]
58	LVDVLEDKLKGEMMD	acetylation	[2]
58	LVDVLEDKLKGEMMD	ubiquitination	[1]
77	SLFLQTPKIVADKDY	ubiquitination	[1]
82	TPKIVADKDYSVTAN	ubiquitination	[1]
119	QRNVNVFKFIIPQIV	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Glycolysis; NAD; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 198 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004459; F:L-lactate dehydrogenase activity; IDA:MGI.
 GO:0051287; F:NAD binding; IEA:Compara.
 GO:0044262; P:cellular carbohydrate metabolic process; IEA:InterPro.
 GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
 GO:0006089; P:lactate metabolic process; IEA:Compara.
 GO:0019674; P:NAD metabolic process; IEA:Compara. 

Interpro

 IPR001557; L-lactate/malate_DH.
 IPR011304; L-lactate_DH.
 IPR018177; L-lactate_DH_AS.
 IPR022383; Lactate/malate_DH_C.
 IPR001236; Lactate/malate_DH_N.
 IPR015955; Lactate_DH/Glyco_Ohase_4_C.
 IPR016040; NAD(P)-bd_dom. 

Pfam

 PF02866; Ldh_1_C
 PF00056; Ldh_1_N 

SMART

  

PROSITE

 PS00064; L_LDH 

PRINTS

 PR00086; LLDHDRGNASE.