UniProt Accession

 PPR18_HUMAN; Q6NYC8; A2AB01; A2AIB8; A4UBI6; A6NCB7; A8MSS7; B7ZCV7; Q68CK8; Q6ZUJ6; Q8NDQ4; Q8TF52; Q9BRL9 

Genbank Protein ID

 AB075829; AB073600; AK124880; AK125639; AL832318; BX647622; DQ988947; AL845353; AL732442; AL662797; AL662798; AL662798; AL662797; CR936878; CR753328; BX908728; CR788240; CR753328; CR936878; CR759873; CH471081; BC006176; BC066644 

Genbank Nucleotide ID

 BAB85535.1; BAD38640.1; BAG54110.1; BAC86229.1; CAD38613.1; CAI46080.1; ABL61261.1; CAX11917.1; CAM25008.1; CAM25509.1; CAM25509.1; CAM25551.1; CAM25551.1; CAQ06808.1; CAQ06808.1; CAQ07426.1; CAQ07566.1; CAQ07800.1; CAQ07800.1; CAQ08685.1; EAX03318.1; AAH06176.1; AAH66644.1 

Protein Name

 Phostensin 

Protein Synonyms/Alias

 Protein phosphatase 1 F-actin cytoskeleton-targeting subunit; Protein phosphatase 1 regulatory subunit 18 

Gene Name

 PPP1R18 

Gene Synonyms/Alias

 HKMT1098; KIAA1949 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
457	SRLFYGVKAGPGVGA	ubiquitination	[1, 2, 3]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 May target protein phosphatase 1 to F-actin cytoskeleton. 

Sequence Annotation

 MOD_RES 54 54 Phosphoserine.
 MOD_RES 133 133 Phosphoserine.
 MOD_RES 175 175 Phosphoserine.
 MOD_RES 195 195 Phosphoserine.
 MOD_RES 199 199 Phosphothreonine.
 MOD_RES 224 224 Phosphoserine.
 MOD_RES 368 368 Phosphoserine.
 MOD_RES 530 530 Phosphoserine (By similarity).  

Keyword

 Actin-binding; Alternative splicing; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 613 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. 

Interpro

 IPR025903; Phostensin/Taperin_N_dom.
 IPR025907; Phostensin/Taperin_PP1-bd_dom.
 IPR026671; PPP1R18/Tprn. 

Pfam

 PF13914; Phostensin
 PF13916; Phostensin_N 

SMART

  

PROSITE

  

PRINTS