CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001105
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Frizzled-7 
Protein Synonyms/Alias
 Fz-7; hFz7; FzE3 
Gene Name
 FZD7 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
137GCEALMNKFGFQWPEubiquitination[1]
569HRLSHSSKGETAV**ubiquitination[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. 
Sequence Annotation
 DOMAIN 44 163 FZ.
 MOTIF 552 557 Lys-Thr-X-X-X-Trp motif, mediates
 MOTIF 572 574 PDZ-binding.
 CARBOHYD 63 63 N-linked (GlcNAc...) (Potential).
 CARBOHYD 164 164 N-linked (GlcNAc...) (Potential).
 DISULFID 49 110 By similarity.
 DISULFID 57 103 By similarity.
 DISULFID 94 131 By similarity.
 DISULFID 120 160 By similarity.
 DISULFID 124 148 By similarity.  
Keyword
 Cell membrane; Complete proteome; Developmental protein; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism; Receptor; Reference proteome; Signal; Transducer; Transmembrane; Transmembrane helix; Ubl conjugation; Wnt signaling pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 574 AA 
Protein Sequence
MRDPGAAAPL SSLGLCALVL ALLGALSAGA GAQPYHGEKG ISVPDHGFCQ PISIPLCTDI 60
AYNQTILPNL LGHTNQEDAG LEVHQFYPLV KVQCSPELRF FLCSMYAPVC TVLDQAIPPC 120
RSLCERARQG CEALMNKFGF QWPERLRCEN FPVHGAGEIC VGQNTSDGSG GPGGGPTAYP 180
TAPYLPDLPF TALPPGASDG RGRPAFPFSC PRQLKVPPYL GYRFLGERDC GAPCEPGRAN 240
GLMYFKEEER RFARLWVGVW SVLCCASTLF TVLTYLVDMR RFSYPERPII FLSGCYFMVA 300
VAHVAGFLLE DRAVCVERFS DDGYRTVAQG TKKEGCTILF MVLYFFGMAS SIWWVILSLT 360
WFLAAGMKWG HEAIEANSQY FHLAAWAVPA VKTITILAMG QVDGDLLSGV CYVGLSSVDA 420
LRGFVLAPLF VYLFIGTSFL LAGFVSLFRI RTIMKHDGTK TEKLEKLMVR IGVFSVLYTV 480
PATIVLACYF YEQAFREHWE RTWLLQTCKS YAVPCPPGHF PPMSPDFTVF MIKYLMTMIV 540
GITTGFWIWS GKTLQSWRRF YHRLSHSSKG ETAV 574 
Gene Ontology
 GO:0045177; C:apical part of cell; IBA:RefGenome.
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0016021; C:integral to membrane; TAS:BHF-UCL.
 GO:0032589; C:neuron projection membrane; IBA:RefGenome.
 GO:0004930; F:G-protein coupled receptor activity; IEA:UniProtKB-KW.
 GO:0042813; F:Wnt-activated receptor activity; IBA:RefGenome.
 GO:0007409; P:axonogenesis; IBA:RefGenome.
 GO:0007420; P:brain development; IBA:RefGenome.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IDA:UniProtKB.
 GO:0071300; P:cellular response to retinoic acid; ISS:UniProtKB.
 GO:0007199; P:G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; IBA:RefGenome.
 GO:0008406; P:gonad development; IBA:RefGenome.
 GO:0060231; P:mesenchymal to epithelial transition; IMP:BHF-UCL.
 GO:0010812; P:negative regulation of cell-substrate adhesion; IMP:BHF-UCL.
 GO:0042666; P:negative regulation of ectodermal cell fate specification; IMP:BHF-UCL.
 GO:0038031; P:non-canonical Wnt receptor signaling pathway via JNK cascade; IMP:BHF-UCL.
 GO:0060054; P:positive regulation of epithelial cell proliferation involved in wound healing; IMP:BHF-UCL.
 GO:0046330; P:positive regulation of JNK cascade; IC:BHF-UCL.
 GO:0042327; P:positive regulation of phosphorylation; IDA:BHF-UCL.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.
 GO:0035412; P:regulation of catenin import into nucleus; IMP:BHF-UCL.
 GO:0014834; P:satellite cell maintenance involved in skeletal muscle regeneration; IEA:Compara.
 GO:0048103; P:somatic stem cell division; IEA:Compara.
 GO:0019827; P:stem cell maintenance; IMP:BHF-UCL.
 GO:0034446; P:substrate adhesion-dependent cell spreading; IEA:Compara.
 GO:0033077; P:T cell differentiation in thymus; IEA:Compara.
 GO:0001944; P:vasculature development; IBA:RefGenome.
 GO:0007223; P:Wnt receptor signaling pathway, calcium modulating pathway; IBA:RefGenome. 
Interpro
 IPR000539; Frizzled.
 IPR015526; Frizzled/SFRP.
 IPR020067; Frizzled_dom.
 IPR026552; FZD7.
 IPR017981; GPCR_2-like. 
Pfam
 PF01534; Frizzled
 PF01392; Fz 
SMART
 SM00063; FRI 
PROSITE
 PS50038; FZ
 PS50261; G_PROTEIN_RECEP_F2_4 
PRINTS
 PR00489; FRIZZLED.