| Tag | Content |
|---|
| CPLM ID | CPLM-013205 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Poly [ADP-ribose] polymerase 14 |
Protein Synonyms/Alias | PARP-14; ADP-ribosyltransferase diphtheria toxin-like 8; ARTD8; B aggressive lymphoma protein 2 |
Gene Name | PARP14 |
Gene Synonyms/Alias | BAL2; KIAA1268 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 380 | ESTTQKIKREEQSLK | ubiquitination | [1] | | 747 | NASNEDLKHYGGLAA | ubiquitination | [1] | | 1122 | SDKIPKAKDTQGFYG | ubiquitination | [1] | | 1276 | AIEDFVQKGSAQSVK | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Enhances STAT6-dependent transcription (By similarity). Has ADP-ribosyltransferase activity. |
Sequence Annotation | DOMAIN 791 978 Macro 1.
DOMAIN 1003 1190 Macro 2.
DOMAIN 1216 1387 Macro 3.
DOMAIN 1523 1601 WWE.
DOMAIN 1605 1801 PARP catalytic. |
Keyword | 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Glycosyltransferase; NAD; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1801 AA |
Protein Sequence | MAVPGSFPLL VEGSWGPDPP KNLNTKLQMY FQSPKRSGGG ECEVRQDPRS PSRFLVFFYP 60
EDVRQKVLER KNHELVWQGK GTFKLTVQLP ATPDEIDHVF EEELLTKESK TKEDVKEPDT 120
IRFVDDCTKH HSIKQLQLSP RLLEVTNTIR VENLPPGADD YSLKLFFENP YNGGGRVANV 180
EYFPEESSAL IEFFDRKVLD TIMATKLDFN KMPLSVFPYY ASLGTALYGK EKPLIKLPAP 240
FEESLDLPLW KFLQKKNHLI EEINDEMRRC HCELTWSQLS GKVTIRPAAT LVNEGRPRIK 300
TWQADTSTTL SSIRSKYKVN PIKVDPTMWD TIKNDVKDDR ILIEFDTLKE MVILAGKSED 360
VQSIEVQVRE LIESTTQKIK REEQSLKEKM IISPGRYFLL CHSSLLDHLL TECPEIEICY 420
DRVTQHLCLK GPSADVYKAK CEIQEKVYTM AQKNIQVSPE IFQFLQQVNW KEFSKCLFIA 480
QKILALYELE GTTVLLTSCS SEALLEAEKQ MLSALNYKRI EVENKEVLHG KKWKGLTHNL 540
LKKQNSSPNT VIINELTSET TAEVIITGCV KEVNETYKLL FNFVEQNMKI ERLVEVKPSL 600
VIDYLKTEKK LFWPKIKKVN VQVSFNPENK QKGILLTGSK TEVLKAVDIV KQVWDSVCVK 660
SVHTDKPGAK QFFQDKARFY QSEIKRLFGC YIELQENEVM KEGGSPAGQK CFSRTVLAPG 720
VVLIVQQGDL ARLPVDVVVN ASNEDLKHYG GLAAALSKAA GPELQADCDQ IVKREGRLLP 780
GNATISKAGK LPYHHVIHAV GPRWSGYEAP RCVYLLRRAV QLSLCLAEKY KYRSIAIPAI 840
SSGVFGFPLG RCVETIVSAI KENFQFKKDG HCLKEIYLVD VSEKTVEAFA EAVKTVFKAT 900
LPDTAAPPGL PPAAAGPGKT SWEKGSLVSP GGLQMLLVKE GVQNAKTDVV VNSVPLDLVL 960
SRGPLSKSLL EKAGPELQEE LDTVGQGVAV SMGTVLKTSS WNLDCRYVLH VVAPEWRNGS 1020
TSSLKIMEDI IRECMEITES LSLKSIAFPA IGTGNLGFPK NIFAELIISE VFKFSSKNQL 1080
KTLQEVHFLL HPSDHENIQA FSDEFARRAN GNLVSDKIPK AKDTQGFYGT VSSPDSGVYE 1140
MKIGSIIFQV ASGDITKEEA DVIVNSTSNS FNLKAGVSKA ILECAGQNVE RECSQQAQQR 1200
KNDYIITGGG FLRCKNIIHV IGGNDVKSSV SSVLQECEKK NYSSICLPAI GTGNAKQHPD 1260
KVAEAIIDAI EDFVQKGSAQ SVKKVKVVIF LPQVLDVFYA NMKKREGTQL SSQQSVMSKL 1320
ASFLGFSKQS PQKKNHLVLE KKTESATFRV CGENVTCVEY AISWLQDLIE KEQCPYTSED 1380
ECIKDFDEKE YQELNELQKK LNINISLDHK RPLIKVLGIS RDVMQARDEI EAMIKRVRLA 1440
KEQESRADCI SEFIEWQYND NNTSHCFNKM TNLKLEDARR EKKKTVDVKI NHRHYTVNLN 1500
TYTATDTKGH SLSVQRLTKS KVDIPAHWSD MKQQNFCVVE LLPSDPEYNT VASKFNQTCS 1560
HFRIEKIERI QNPDLWNSYQ AKKKTMDAKN GQTMNEKQLF HGTDAGSVPH VNRNGFNRSY 1620
AGKNAVAYGK GTYFAVNANY SANDTYSRPD ANGRKHVYYV RVLTGIYTHG NHSLIVPPSK 1680
NPQNPTDLYD TVTDNVHHPS LFVAFYDYQA YPEYLITFRK 1720 |
Gene Ontology | GO:0005737; C:cytoplasm; IDA:HPA. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IDA:HPA. GO:0003950; F:NAD+ ADP-ribosyltransferase activity; IEA:EC. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |