| Tag | Content |
|---|
| CPLM ID | CPLM-022948 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-dependent RNA helicase DDX25 |
Protein Synonyms/Alias | DEAD box protein 25; Gonadotropin-regulated testicular RNA helicase |
Gene Name | DDX25 |
Gene Synonyms/Alias | GRTH |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 30 | SNLSQPRKNLWGIKS | ubiquitination | [1] | | 87 | HRVEVLQKDPSSPLY | ubiquitination | [1] | | 105 | TFEELRLKEELLKGI | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development (By similarity). |
Sequence Annotation | DOMAIN 130 300 Helicase ATP-binding.
DOMAIN 311 478 Helicase C-terminal.
NP_BIND 143 150 ATP (By similarity).
MOTIF 61 74 Nuclear export signal (By similarity).
MOTIF 97 125 Q motif.
MOTIF 100 114 Nuclear localization signal (By
MOTIF 247 250 DEAD box. |
Keyword | 3D-structure; Alternative initiation; ATP-binding; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Helicase; Hydrolase; mRNA transport; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; RNA-binding; Spermatogenesis; Translation regulation; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 483 AA |
Protein Sequence | MASLLWGGDA GAAESERLNS HFSNLSQPRK NLWGIKSTAV RNIDGSINNI NEDDEEDVVD 60
LAANSLLNKL IHQSLVESSH RVEVLQKDPS SPLYSVKTFE ELRLKEELLK GIYAMGFNRP 120
SKIQEMALPM MLAHPPQNLI AQSQSGTGKT AAFVLAMLSR VNALELFPQC LCLAPTYELA 180
LQTGRVVEQM GKFCVDVQVM YAIRGNRIPR GTDITKQIII GTPGTVLDWC FKLKLIDLTK 240
IRVFVLDEAD VMIDTQGFSD HSIRIQRALP SECQMLLFSA TFEDSVWHFA ERIIPDPNVI 300
KLRKEELTLN NIRQYYVLCE HRKDKYQALC NIYGSITIGQ AIIFCQTRRN AKWLTVEMIQ 360
DGHQVSLLSG ELTVEQRASI IQRFRDGKEK VLITTNVCAR GIDVKQVTIV VNFDLPVKQG 420
EEPDYETYLH RIGRTGRFGK KGLAFNMIEV DELPSLMKIQ DHFNSSIKQL NAEDMDEIEK 480
IDY 483 |
Gene Ontology | GO:0033391; C:chromatoid body; ISS:UniProtKB. GO:0005634; C:nucleus; ISS:UniProtKB. GO:0005524; F:ATP binding; ISS:UniProtKB. GO:0004004; F:ATP-dependent RNA helicase activity; ISS:UniProtKB. GO:0003723; F:RNA binding; IEA:UniProtKB-KW. GO:0006406; P:mRNA export from nucleus; ISS:UniProtKB. GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. GO:0006417; P:regulation of translation; ISS:UniProtKB. GO:0007286; P:spermatid development; ISS:UniProtKB. |
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PROSITE | |
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