UniProt Accession

 SRP21_YEAST; P32342; D6VXG8 

Genbank Protein ID

 S44213; Z28122; AY558352; BK006944 

Genbank Nucleotide ID

 AAB23073.1; CAA81963.1; AAS56678.1; DAA09038.1 

Protein Name

 Signal recognition particle subunit SRP21 

Protein Synonyms/Alias

 Signal recognition particle 21 kDa protein 

Gene Name

 SRP21 

Gene Synonyms/Alias

 YKL122C; YKL527 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
31	TLFSISYKPPTQKTD	ubiquitination	[1]
36	SYKPPTQKTDTKVSF	ubiquitination	[1]
106	SSKKIKGKSIQDIVG	ubiquitination	[1]

Reference

 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 

Functional Description

 Signal-recognition-particle (SRP) assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum (ER) membrane. SRP is required for the cotranslational protein translocation for ER import and preferentially recognizes strongly hydrophobic signal sequences. It is involved in targeting the nascent chain-ribosome (RNC) complex to the ER and is proposed to participate in the arrest of nascent chain elongation during membrane targeting. 

Sequence Annotation

 MOD_RES 2 2 N-acetylserine.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Reference proteome; Ribonucleoprotein; RNA-binding; Signal recognition particle. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 167 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:SGD.
 GO:0005786; C:signal recognition particle, endoplasmic reticulum targeting; IDA:SGD.
 GO:0008312; F:7S RNA binding; IEA:InterPro.
 GO:0005048; F:signal sequence binding; IPI:SGD.
 GO:0045900; P:negative regulation of translational elongation; IEA:InterPro.
 GO:0006617; P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition; IC:SGD. 

Interpro

 IPR008832; Signal_recog_particle_SRP9. 

Pfam

 PF05486; SRP9-21 

SMART

  

PROSITE

  

PRINTS