CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018939
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial 
Protein Synonyms/Alias
 Succinyl-CoA synthetase subunit alpha; SCS-alpha 
Gene Name
 Scsalpha 
Gene Synonyms/Alias
 CG1065 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
313IVTRSPAKMGHELFKacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity (By similarity). 
Sequence Annotation
 ACT_SITE 281 281 Tele-phosphohistidine intermediate (By  
Keyword
 Complete proteome; GTP-binding; Ligase; Mitochondrion; Nucleotide-binding; Phosphoprotein; Reference proteome; Transit peptide; Tricarboxylic acid cycle. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 328 AA 
Protein Sequence
MAASMRALLK VRDGFVAGVR CNSQYNKTRG NLKLNGDSRV ICQGFTGKQG TFHSQQALEY 60
GTKLVGGISP KKGGTQHLGL PVFASVAEAK KATDPHATVI YVPPPGAAAA IIEALEAEIP 120
LIVCITEGVP QHDMVKVKHA LISQSKSRLV GPNCPGIIAP EQCKIGIMPG HIHKRGKIGV 180
VSRSGTLTYE AVHQTTEVGL GQTLCVGIGG DPFNGTDFID CLEVFLKDPE TKGIILIGEI 240
GGVAEEKAAD YLTEYNSGIK AKPVVSFIAG VSAPPGRRMG HAGAIISGGK GGANDKIAAL 300
EKAGVIVTRS PAKMGHELFK EMKRLELV 328 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0003878; F:ATP citrate synthase activity; IEA:InterPro.
 GO:0048037; F:cofactor binding; IEA:InterPro.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0004775; F:succinate-CoA ligase (ADP-forming) activity; IEA:EC.
 GO:0004776; F:succinate-CoA ligase (GDP-forming) activity; IEA:EC.
 GO:0022008; P:neurogenesis; IMP:FlyBase.
 GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-UniPathway. 
Interpro
 IPR017440; Cit_synth/succinyl-CoA_lig_AS.
 IPR003781; CoA-bd.
 IPR005810; CoA_lig_alpha.
 IPR005811; CoA_ligase.
 IPR016040; NAD(P)-bd_dom.
 IPR016102; Succinyl-CoA_synth-like. 
Pfam
 PF02629; CoA_binding
 PF00549; Ligase_CoA 
SMART
 SM00881; CoA_binding 
PROSITE
 PS01216; SUCCINYL_COA_LIG_1
 PS00399; SUCCINYL_COA_LIG_2 
PRINTS
 PR01798; SCOASYNTHASE.