CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009128
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Anthrax toxin receptor 2 
Protein Synonyms/Alias
 Capillary morphogenesis gene 2 protein; CMG-2 
Gene Name
 ANTXR2 
Gene Synonyms/Alias
 CMG2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
268ETYTTSVKPVSVQLNubiquitination[1]
346WFWPLCCKVVIKDPPubiquitination[1]
372EEPLPTKKWPTVDASubiquitination[2]
399MEVRWGDKGSTEEGAubiquitination[1]
443THQPPQTKWYTPIKGubiquitination[2, 3]
449TKWYTPIKGRLDALWubiquitination[3, 4]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Necessary for cellular interactions with laminin and the extracellular matrix. 
Sequence Annotation
 DOMAIN 44 213 VWFA.
 METAL 52 52 Divalent metal cation.
 METAL 54 54 Divalent metal cation.
 METAL 118 118 Divalent metal cation.
 MOD_RES 147 147 Phosphothreonine.
 CARBOHYD 250 250 N-linked (GlcNAc...) (Potential).
 CARBOHYD 260 260 N-linked (GlcNAc...) (Potential).
 DISULFID 39 218  
Keyword
 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Disease mutation; Disulfide bond; Endoplasmic reticulum; Glycoprotein; Membrane; Metal-binding; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Secreted; Signal; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 489 AA 
Protein Sequence
MVAERSPARS PGSWLFPGLW LLVLSGPGGL LRAQEQPSCR RAFDLYFVLD KSGSVANNWI 60
EIYNFVQQLA ERFVSPEMRL SFIVFSSQAT IILPLTGDRG KISKGLEDLK RVSPVGETYI 120
HEGLKLANEQ IQKAGGLKTS SIIIALTDGK LDGLVPSYAE KEAKISRSLG ASVYCVGVLD 180
FEQAQLERIA DSKEQVFPVK GGFQALKGII NSILAQSCTE ILELQPSSVC VGEEFQIVLS 240
GRGFMLGSRN GSVLCTYTVN ETYTTSVKPV SVQLNSMLCP APILNKAGET LDVSVSFNGG 300
KSVISGSLIV TATECSNGIA AIIVILVLLL LLGIGLMWWF WPLCCKVVIK DPPPPPAPAP 360
KEEEEEPLPT KKWPTVDASY YGGRGVGGIK RMEVRWGDKG STEEGARLEK AKNAVVKIPE 420
ETEEPIRPRP PRPKPTHQPP QTKWYTPIKG RLDALWALLR RQYDRVSLMR PQEGDEVCIW 480
ECIEKELTA 489 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004872; F:receptor activity; IEA:InterPro.
 GO:0022414; P:reproductive process; IEA:Compara. 
Interpro
 IPR017360; Anthrax_toxin_rcpt.
 IPR008399; Anthrax_toxin_rcpt_C.
 IPR008400; Anthrax_toxin_rcpt_extracel.
 IPR002035; VWF_A. 
Pfam
 PF05586; Ant_C
 PF05587; Anth_Ig
 PF00092; VWA 
SMART
 SM00327; VWA 
PROSITE
 PS50234; VWFA 
PRINTS