CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007160
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 1-pyrroline-5-carboxylate dehydrogenase 
Protein Synonyms/Alias
 P5C dehydrogenase 
Gene Name
 rocA 
Gene Synonyms/Alias
 BSU37780; ipa-76d 
Created Date
 July 27, 2013 
Organism
 Bacillus subtilis (strain 168) 
NCBI Taxa ID
 224308 
Lysine Modification
Position
Peptide
Type
References
90LQAFDSWKKQRPEHRacetylation[1]
125YLVKEAGKPWKEADAacetylation[1]
290VIAEMGGKDTVLVDKacetylation[1]
297KDTVLVDKDADLDLAacetylation[1]
373ASYNKVMKYIEIGKSacetylation[1]
Reference
 [1] The acetylproteome of Gram-positive model bacterium Bacillus subtilis.
 Kim D, Yu BJ, Kim JA, Lee YJ, Choi SG, Kang S, Pan JG.
 Proteomics. 2013 May;13(10-11):1726-36. [PMID: 23468065] 
Functional Description
  
Sequence Annotation
 ACT_SITE 286 286 By similarity.
 ACT_SITE 320 320 By similarity.  
Keyword
 Complete proteome; NAD; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 515 AA 
Protein Sequence
MTVTYAHEPF TDFTEAKNKT AFGESLAFVN TQLGKHYPLV INGEKIETDR KIISINPANK 60
EEIIGYASTA DQELAEKAMQ AALQAFDSWK KQRPEHRANI LFKAAAILRR RKHEFSSYLV 120
KEAGKPWKEA DADTAEAIDF LEFYARQMLK LKEGAPVKSR AGEVNQYHYE ALGVGIVISP 180
FNFPLAIMAG TAVAAIVTGN TILLKPADAA PVVAAKFVEV MEEAGLPNGV LNYIPGDGAE 240
IGDFLVEHPK TRFVSFTGSR AVGCRIYERA AKVQPGQKWL KRVIAEMGGK DTVLVDKDAD 300
LDLAASSIVY SAFGYSGQKC SAGSRAVIHQ DVYDEVVEKA VALTKTLTVG NPEDPDTYMG 360
PVIHEASYNK VMKYIEIGKS EGKLLAGGEG DDSKGYFIQP TIFADVDENA RLMQEEIFGP 420
VVAICKARDF DHMLEIANNT EYGLTGALLT KNRAHIERAR EDFHVGNLYF NRGCTGAIVG 480
YQPFGGFNMS GTDSKAGGPD YLILHMQAKT TSEAF 515 
Gene Ontology
 GO:0003842; F:1-pyrroline-5-carboxylate dehydrogenase activity; IEA:HAMAP.
 GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
 GO:0006537; P:glutamate biosynthetic process; IEA:HAMAP.
 GO:0006561; P:proline biosynthetic process; IEA:InterPro.
 GO:0010133; P:proline catabolic process to glutamate; IEA:UniProtKB-UniPathway. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR005932; Delta1-pyrroline-5-COlate_DH-2. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS