| Tag | Content |
|---|
| CPLM ID | CPLM-019895 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Lipolysis-stimulated lipoprotein receptor |
Protein Synonyms/Alias | Lipolysis-stimulated receptor; Liver-specific bHLH-Zip transcription factor; Liver-specific gene on mouse chromosome 7 protein |
Gene Name | Lsr |
Gene Synonyms/Alias | Lisch7 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 282 | YTHLSPAKTPPPPPA | ubiquitination | [1] | | 353 | RVLYYMEKELANFDP | ubiquitination | [1] | | 538 | RLLEEALKKKGAGER | ubiquitination | [1] | | 539 | LLEEALKKKGAGERR | ubiquitination | [1] | | 582 | ASRERRMKKNLALSR | ubiquitination | [1] | | 583 | SRERRMKKNLALSRE | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). |
Sequence Annotation | DOMAIN 89 181 Ig-like V-type.
MOD_RES 132 132 Phosphothreonine.
MOD_RES 307 307 Phosphoserine.
MOD_RES 379 379 Phosphoserine.
MOD_RES 436 436 Phosphoserine.
MOD_RES 454 454 Phosphoserine.
MOD_RES 471 471 Phosphoserine (By similarity).
MOD_RES 473 473 Phosphoserine.
MOD_RES 478 478 Phosphotyrosine.
MOD_RES 591 591 Phosphoserine.
DISULFID 113 165 By similarity. |
Keyword | Alternative splicing; Cell membrane; Chylomicron; Complete proteome; Disulfide bond; Immunoglobulin domain; LDL; Membrane; Phosphoprotein; Receptor; Reference proteome; Signal; Transmembrane; Transmembrane helix; VLDL. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 594 AA |
Protein Sequence | MAPAASACAG APGSHPATTI FVCLFLIIYC PDRASAIQVT VPDPYHVVIL FQPVTLHCTY 60
QMSNTLTAPI VIWKYKSFCR DRVADAFSPA SVDNQLNAQL AAGNPGYNPY VECQDSVRTV 120
RVVATKQGNA VTLGDYYQGR RITITGNADL TFEQTAWGDS GVYYCSVVSA QDLDGNNEAY 180
AELIVLGRTS EAPELLPGFR AGPLEDWLFV VVVCLASLLF FLLLGICWCQ CCPHTCCCYV 240
RCPCCPDKCC CPEALYAAGK AATSGVPSIY APSIYTHLSP AKTPPPPPAM IPMRPPYGYP 300
GDFDRTSSVG GHSSQVPLLR EVDGSVSSEV RSGYRIQANQ QDDSMRVLYY MEKELANFDP 360
SRPGPPNGRV ERAMSEVTSL HEDDWRSRPS RAPALTPIRD EEWNRHSPRS PRTWEQEPLQ 420
EQPRGGWGSG RPRARSVDAL DDINRPGSTE SGRSSPPSSG RRGRAYAPPR SRSRDDLYDP 480
DDPRDLPHSR DPHYYDDLRS RDPRADPRSR QRSHDPRDAG FRSRDPQYDG RLLEEALKKK 540
GAGERRRVYR EEEEEEEEGH YPPAPPPYSE TDSQASRERR MKKNLALSRE SLVV 594 |
Gene Ontology | GO:0042627; C:chylomicron; IEA:UniProtKB-KW. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0034362; C:low-density lipoprotein particle; IEA:UniProtKB-KW. GO:0005886; C:plasma membrane; IDA:HGNC. GO:0034361; C:very-low-density lipoprotein particle; IEA:UniProtKB-KW. GO:0030228; F:lipoprotein particle receptor activity; TAS:HGNC. GO:0030169; F:low-density lipoprotein particle binding; TAS:HGNC. GO:0009790; P:embryo development; IMP:HGNC. GO:0042953; P:lipoprotein transport; TAS:HGNC. GO:0001889; P:liver development; IMP:HGNC. GO:0019216; P:regulation of lipid metabolic process; IEA:Compara. |
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