CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032209
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-complex protein 1 subunit epsilon 
Protein Synonyms/Alias
 cDNA, FLJ79275, highly similar to T-complex protein 1 subunit epsilon 
Gene Name
 CCT5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
21LGPNGLDKMMVDKDGubiquitination[1]
26LDKMMVDKDGDVTVTubiquitination[1, 2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 503 AA 
Protein Sequence
MAAKAVANTM RTSLGPNGLD KMMVDKDGDV TVTNDGATIL SMMDVDHQIA KLMVELSKSQ 60
DDEIGDGTTG VVVLAGALLE EAEQLLDRGI HPIRIADGYE QAARVAIEHL DKISDSVLVD 120
IKDTEPLIQT AKTTLGSKVV NSCHRQMAEI AVNAVLTVAD MERRDVDFEL IKVEGKVGGR 180
LEDTKLIKGV IVDKDFSHPQ MPKKVEDAKI AILTCPFEPP KPKTKHKLDV TSVEDYKALQ 240
KYEKEKFEEM IQQIKETGAN LAICQWGFDD EANHLLLQNN LPAVRWVGGP EIELIAIATG 300
GRIVPRFSEL TAEKLGFAGL VQEISFGTTK DKMLVIEQCK NSRAVTIFIR GGNKMIIEEA 360
KRSLHDALCV IRNLIRDNRV VYGGGAAEIS CALAVSQEAD KCPTLEQYAM RAFADALEVI 420
PMALSENSGM NPIQTMTEVR ARQVKEMNPA LGIDCLHKGT NDMKQQHVIE TLIGKKQQIS 480
LATQMVRMIL KIDDIRKPGE SEE 503 
Gene Ontology
 GO:0005832; C:chaperonin-containing T-complex; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR012718; Chap_CCT_epsi.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00750; TCP1_1
 PS00751; TCP1_2
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.