CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-036024
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Protein RTEL1-TNFRSF6B 
Protein Synonyms/Alias
  
Gene Name
 RTEL1-TNFRSF6B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
35VLECLQQKVNGILESubiquitination[1]
134RNTSYRPKVCVLGSRubiquitination[1]
199LDIEDLVKSGSKHRVubiquitination[1]
216YYLSRNLKQQADIIFubiquitination[1]
233YNYLLDAKSRRAHNIubiquitination[1, 2]
571ECLSSLGKALGNIARubiquitination[1, 2, 3, 4]
614ARKMEALKPLFVEPRubiquitination[1]
623LFVEPRSKGSFSETIubiquitination[1]
654FLAVCRGKASEGLDFubiquitination[1, 2, 4]
687MDPRVVLKMQFLDEMubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 785 AA 
Protein Sequence
MPKIVLNGVT VDFPFQPYKC QQEYMTKVLE CLQQKVNGIL ESPTGTGKTL CLLCTTLAWR 60
EHLRDGISAR KIAERAQGEL FPDRALSSWG NAAAAAGDPI ACYTDIPKII YASRTHSQLT 120
QVINELRNTS YRPKVCVLGS REQLCIHPEV KKQESNHLQI HLCRKKVASR SCHFYNNVEE 180
KSLEQELASP ILDIEDLVKS GSKHRVCPYY LSRNLKQQAD IIFMPYNYLL DAKSRRAHNI 240
DLKGTVVIFD EAHNVEKMCE ESASFDLTPH DLASGLDVID QVLEEQTKAA QQGEPHPEFS 300
ADSPSPGLNM ELEDIAKLKS KCCPPRLLAA GWGLLLARRW VTPPRPTVIL LRLEGAIDAV 360
ELPGDDSGVT KPGSYIFELF AEAQITFQTK GCILDSLDQI IQHLAGRAGV FTNTAGLQKL 420
ADIIQIVFSV DPSEGSPGSP AGLGALQSYK VHIHPDAGHR RTAQRSDAWS TTAARKRGKV 480
LSYWCFSPGH SMHELVRQGV RSLILTSGTL APVSSFALEM QIPFPVCLEN PHIIDKHQIW 540
VGVVPRGPDG AQLSSAFDRR FSEECLSSLG KALGNIARVV PYGLLIFFPS YPVMEKSLEF 600
WRARDLARKM EALKPLFVEP RSKGSFSETI SAYYARVAAP GSTGATFLAV CRGKASEGLD 660
FSDTNGRGVI VTGLPYPPRM DPRVVLKMQF LDEMKGQGGA GGQFLSGQEW YRQQASRAVN 720
QAIGRVIRHR QDYGAVFLCD HRCQRRPPGL QHPVCVEKML SARPSRLAPS SPPGKLRVWT 780
CMSPA 785 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004003; F:ATP-dependent DNA helicase activity; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro. 
Interpro
 IPR006555; ATP-dep_Helicase_C.
 IPR010614; DEAD_2.
 IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
 IPR006554; Helicase-like_DEXD_c2.
 IPR027417; P-loop_NTPase. 
Pfam
 PF06733; DEAD_2
 PF13307; Helicase_C_2 
SMART
 SM00488; DEXDc2
 SM00491; HELICc2 
PROSITE
 PS51193; HELICASE_ATP_BIND_2 
PRINTS