UniProt Accession

 PROX1_HUMAN; Q92786; A6NK29; A8K2B1; Q5SW76; Q8TB91 

Genbank Protein ID

 U44060; AK290176; AL606537; AC011700; CH471100; BC024201 

Genbank Nucleotide ID

 AAC50656.1; BAF82865.1; CAI15309.1; CAI15309.1; EAW93360.1; AAH24201.1 

Protein Name

 Prospero homeobox protein 1 

Protein Synonyms/Alias

 Homeobox prospero-like protein PROX1; PROX-1 

Gene Name

 PROX1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
556	GLSLSLIKSECGDLQ	sumoylation	[1, 2]

Reference

 [1] Modulation of transcriptional corepressor activity of prospero-related homeobox protein (Prox1) by SUMO modification.
 Shan SF, Wang LF, Zhai JW, Qin Y, Ouyang HF, Kong YY, Liu J, Wang Y, Xie YH.
 FEBS Lett. 2008 Nov 12;582(27):3723-8. [PMID: 18948102]
 [2] Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells.
 Pan MR, Chang TM, Chang HC, Su JL, Wang HW, Hung WC.
 J Cell Sci. 2009 Sep 15;122(Pt 18):3358-64. [PMID: 19706680] 

Functional Description

 May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons (By similarity). 

Sequence Annotation

 DNA_BIND 573 635 Prospero-type homeobox.
 REGION 636 737 Prospero-like.
 MOD_RES 177 177 Phosphoserine (By similarity).
 MOD_RES 179 179 Phosphoserine (By similarity).
 MOD_RES 291 291 Phosphoserine (By similarity).
 MOD_RES 511 511 Phosphoserine (By similarity).
 MOD_RES 514 514 Phosphoserine (By similarity).
 MOD_RES 650 650 Phosphothreonine (By similarity).  

Keyword

 3D-structure; Complete proteome; Developmental protein; DNA-binding; Homeobox; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 737 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; ISS:BHF-UCL.
 GO:0043565; F:sequence-specific DNA binding; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; IDA:BHF-UCL.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
 GO:0060414; P:aorta smooth muscle tissue morphogenesis; ISS:BHF-UCL.
 GO:0055009; P:atrial cardiac muscle tissue morphogenesis; ISS:BHF-UCL.
 GO:0001709; P:cell fate determination; IEA:Compara.
 GO:0021707; P:cerebellar granule cell differentiation; ISS:BHF-UCL.
 GO:0021542; P:dentate gyrus development; ISS:BHF-UCL.
 GO:0021516; P:dorsal spinal cord development; ISS:BHF-UCL.
 GO:0060059; P:embryonic retina morphogenesis in camera-type eye; IEP:BHF-UCL.
 GO:0060214; P:endocardium formation; ISS:BHF-UCL.
 GO:0002194; P:hepatocyte cell migration; IEA:Compara.
 GO:0070365; P:hepatocyte differentiation; IEP:BHF-UCL.
 GO:0072574; P:hepatocyte proliferation; IEA:Compara.
 GO:0001822; P:kidney development; IEP:BHF-UCL.
 GO:0070309; P:lens fiber cell morphogenesis; IEP:BHF-UCL.
 GO:0030324; P:lung development; IEP:BHF-UCL.
 GO:0001946; P:lymphangiogenesis; IDA:BHF-UCL.
 GO:0070858; P:negative regulation of bile acid biosynthetic process; IMP:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; IMP:BHF-UCL.
 GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; IDA:BHF-UCL.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0045071; P:negative regulation of viral genome replication; IDA:BHF-UCL.
 GO:0021915; P:neural tube development; ISS:BHF-UCL.
 GO:0097150; P:neuronal stem cell maintenance; ISS:BHF-UCL.
 GO:0030910; P:olfactory placode formation; ISS:BHF-UCL.
 GO:0046619; P:optic placode formation involved in camera-type eye formation; ISS:BHF-UCL.
 GO:0043049; P:otic placode formation; ISS:BHF-UCL.
 GO:0031016; P:pancreas development; IEP:BHF-UCL.
 GO:0045737; P:positive regulation of cyclin-dependent protein kinase activity; IDA:BHF-UCL.
 GO:0010595; P:positive regulation of endothelial cell migration; IDA:BHF-UCL.
 GO:0001938; P:positive regulation of endothelial cell proliferation; IDA:BHF-UCL.
 GO:2000979; P:positive regulation of forebrain neuron differentiation; ISS:BHF-UCL.
 GO:0060421; P:positive regulation of heart growth; ISS:BHF-UCL.
 GO:2000179; P:positive regulation of neural precursor cell proliferation; ISS:BHF-UCL.
 GO:0060298; P:positive regulation of sarcomere organization; ISS:BHF-UCL.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:BHF-UCL.
 GO:0060849; P:regulation of transcription involved in lymphatic endothelial cell fate commitment; IMP:BHF-UCL.
 GO:0031667; P:response to nutrient levels; IEA:Compara.
 GO:0030240; P:skeletal muscle thin filament assembly; ISS:BHF-UCL.
 GO:0048845; P:venous blood vessel morphogenesis; ISS:BHF-UCL.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; ISS:BHF-UCL.
 GO:0055005; P:ventricular cardiac myofibril development; ISS:BHF-UCL.
 GO:0060412; P:ventricular septum morphogenesis; ISS:BHF-UCL. 

Interpro

 IPR023082; Homeo_prospero_dom.
 IPR009057; Homeodomain-like.
 IPR007738; Prox1. 

Pfam

 PF05044; Prox1 

SMART

  

PROSITE

  

PRINTS