CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014455
UniProt Accession
Genbank Protein ID
 U19894 
Genbank Nucleotide ID
Protein Name
 CD81 antigen 
Protein Synonyms/Alias
 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; CD81 
Gene Name
 Cd81 
Gene Synonyms/Alias
 Tapa1 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
121VNKDQIAKDVKQFYDacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 May play an important role in the regulation of lymphoma cell growth. 
Sequence Annotation
 DISULFID 156 190 By similarity.
 DISULFID 157 175 By similarity.  
Keyword
 Complete proteome; Direct protein sequencing; Disulfide bond; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 236 AA 
Protein Sequence
MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTTLLYLELG DKPAPSTFYV 60
GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI LFACEVAAGI WGFVNKDQIA 120
KDVKQFYDQA LQQAVMDDDA NNAKAVVKTF HETLNCCGSN TLTTLTTAVL RNSLCPSSSN 180
SFTQLLKEDC HQKIDELFSG KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY 236 
Gene Ontology
 GO:0016324; C:apical plasma membrane; IDA:RGD.
 GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
 GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
 GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.
 GO:0043128; P:positive regulation of 1-phosphatidylinositol 4-kinase activity; ISS:UniProtKB.
 GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
 GO:0008104; P:protein localization; ISS:UniProtKB.
 GO:0040008; P:regulation of growth; IEP:RGD.
 GO:0009611; P:response to wounding; IEP:RGD. 
Interpro
 IPR000301; Tetraspanin.
 IPR018499; Tetraspanin/Peripherin.
 IPR018503; Tetraspanin_CS.
 IPR008952; Tetraspanin_EC2. 
Pfam
 PF00335; Tetraspannin 
SMART
  
PROSITE
 PS00421; TM4_1 
PRINTS
 PR00259; TMFOUR.