CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002244
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 60S acidic ribosomal protein P2-alpha 
Protein Synonyms/Alias
 P2A; A2; L12EIB; L44; YP2alpha 
Gene Name
 RPP2A 
Gene Synonyms/Alias
 L12EIB; RPA2; RPL44; RPLA2; YOL039W 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
2******MKYLAAYLLubiquitination[1, 2]
21GNTPDATKIKAILESubiquitination[1]
37GIEIEDEKVSSVLSAubiquitination[2]
48VLSALEGKSVDELITacetylation[3]
48VLSALEGKSVDELITubiquitination[1]
Reference
 [1] Sites of ubiquitin attachment in Saccharomyces cerevisiae.
 Starita LM, Lo RS, Eng JK, von Haller PD, Fields S.
 Proteomics. 2012 Jan;12(2):236-40. [PMID: 22106047]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, VillĂ©n J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [3] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919
Functional Description
 Plays an important role in the elongation step of protein synthesis. 
Sequence Annotation
 MOD_RES 16 16 Phosphothreonine.
 MOD_RES 40 40 Phosphoserine.
 MOD_RES 43 43 Phosphoserine.
 MOD_RES 49 49 Phosphoserine.
 MOD_RES 96 96 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 106 AA 
Protein Sequence
MKYLAAYLLL NAAGNTPDAT KIKAILESVG IEIEDEKVSS VLSALEGKSV DELITEGNEK 60
LAAVPAAGPA SAGGAAAASG DAAAEEEKEE EAAEESDDDM GFGLFD 106 
Gene Ontology
 GO:0022625; C:cytosolic large ribosomal subunit; TAS:SGD.
 GO:0003735; F:structural constituent of ribosome; TAS:SGD.
 GO:0002181; P:cytoplasmic translation; TAS:SGD.
 GO:0006414; P:translational elongation; ISS:SGD. 
Interpro
 IPR001813; Ribosomal_L10/L12.
 IPR027534; Ribosomal_L12. 
Pfam
 PF00428; Ribosomal_60s 
SMART
  
PROSITE
  
PRINTS