UniProt Accession

 BI2L1_HUMAN; Q9UHR4; A4D268; Q75L21; Q75L22; Q96CV4; Q9H5F5; Q9Y2M8 

Genbank Protein ID

 AF119666; AC004841; AC093169; AC093799; AC093799; CH236956; CH471091; BC013888; AK027142 

Genbank Nucleotide ID

 AAF17223.2; AAD20937.1; AAS07549.1; AAS07550.1; EAL23890.1; EAW76706.1; AAH13888.1; BAB15671.1 

Protein Name

 Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 

Protein Synonyms/Alias

 BAI1-associated protein 2-like protein 1; Insulin receptor tyrosine kinase substrate 

Gene Name

 BAIAP2L1 

Gene Synonyms/Alias

 IRTKS 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
106	EIIHELEKKIELDVK	acetylation	[1]
234	ETCVDAIKVPEKIMN	ubiquitination	[2]
238	DAIKVPEKIMNMIEE	ubiquitination	[3, 4]
247	MNMIEEIKTPASTPV	ubiquitination	[4]
496	ENPFATVKLRPTVTN	ubiquitination	[3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. 

Sequence Annotation

 DOMAIN 1 249 IMD.
 DOMAIN 339 402 SH3.
 REGION 483 511 Binds F-actin.
 MOD_RES 248 248 Phosphothreonine.
 MOD_RES 257 257 Phosphothreonine.
 MOD_RES 261 261 Phosphoserine.
 MOD_RES 281 281 Phosphoserine.
 MOD_RES 329 329 Phosphoserine (By similarity).
 MOD_RES 331 331 Phosphoserine.
 MOD_RES 412 412 Phosphothreonine.  

Keyword

 3D-structure; Actin-binding; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 511 AA 

Protein Sequence

Gene Ontology

 GO:0030054; C:cell junction; IDA:HPA.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0070064; F:proline-rich region binding; IDA:UniProtKB.
 GO:0046847; P:filopodium assembly; IEA:InterPro.
 GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IMP:UniProtKB.
 GO:0030838; P:positive regulation of actin filament polymerization; IDA:UniProtKB.
 GO:0009617; P:response to bacterium; IDA:UniProtKB.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR013606; IRSp53/MIM_homology_IMD.
 IPR011511; SH3_2.
 IPR001452; SH3_domain. 

Pfam

 PF08397; IMD
 PF07653; SH3_2 

SMART

 SM00326; SH3 

PROSITE

 PS51338; IMD
 PS50002; SH3 

PRINTS