CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038619
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ubiquitin carboxyl-terminal hydrolase 
Protein Synonyms/Alias
  
Gene Name
 Usp19 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
628DLNRIQNKPYTETVDubiquitination[1]
669DLFQGQYKSKLVCPVubiquitination[1]
753LRLAEVIKNRFHRVFubiquitination[1]
1138RSFIWRDKINDLVEFubiquitination[1]
1154VRNLDLSKFCIGQKEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Metal-binding; Protease; Reference proteome; Thiol protease; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1299 AA 
Protein Sequence
MSAGASATGP RRGPPGLEEA TSKKKQKDRA NLESKDGDAR RVSLPRKEPT KDELLLDWRQ 60
SADEVIVKLR VGTGPVRLED VDAAFTDTDC VVRLPDGRQW GGVFFAEIQS SCTKVQARKG 120
GLLQLVLPKK VPLLTWPSLL KPLGTQELVP GLQCQENGQE LSPIALEPGS EPRRAKQEAR 180
NQKRAQGRGE VGSGAGPGTQ AGPSAKRAVH LRRGPEGEGS MDGPGPQGDA PSFLSDSATQ 240
VEAEEKLCAP PMNTQTSLLS SEKSLALLTV EKTVSPRNDP VAPVMVQDRD PEPEQEDQVK 300
EEMALGADPT ALVEEPESMV NLAFVKNDSY EKGPDSVVVH VYVKEIRRDS SRVLFREQDF 360
TLIFQTRNLI EPEQCTFCFT ASRIDICLRK RQSQRWGGLE APATRGAVGG AKVAVPTGPT 420
PLDSTPPGGG PHPLTGQEEA RAVEKEKPKA RSEDSGLDGV VARTPLEHVA PKPDPHLASP 480
KPTCMVPPMP HSPVSGDSVE EDEEEEKKVC LPGFTGLVNL GNTCFMNSVI QSLSNTRELR 540
DFFHDRSFEA EINYNNPLGT GGRLAIGFAV LLRALWKGTH QAFQPSKLKA IVASKASQFT 600
GYAQHDAQEF MAFLLDGLHE DLNRIQNKPY TETVDSDGRP DEVVAEEAWQ RHKMRNDSFI 660
VDLFQGQYKS KLVCPVCAKV SITFDPFLYL PVPLPQKQKV LPIFYFAREP HSKPIKFLVS 720
VSKENSSASE VLDSLSQSVH VKPENLRLAE VIKNRFHRVF LPSHSLDAVS PTDVLLCFEL 780
LSPELAKERV VVLEVQQRPQ VPSIPISKCA ACQRKQQSEE EKLKRCTRCY RVGYCNQFCQ 840
KTHWPDHKGL CRPENIGYPF LVSVPASRLT YARLAQLLEG YARYSVSVFQ PPFQPGRMAL 900
ESQSPGCTTL LSTSSLEAGD SEREPIQPSE LQLVTPVAEG DTGAHRVWPP ADRGPVPSTS 960
GLSSEMLASG PIEGCPLLAG ERVSRPEAAV PGYQHSSESV NTHTPQFFIY KIDASNREQR 1020
LEDKGETPLE LGDDCSLALV WRNNERLQEF VLVASKELEC AEDPGSAGEA ARAGHFTLDQ 1080
CLNLFTRPEV LAPEEAWYCP QCKQHREASK QLLLWRLPNV LIVQLKRFSF RSFIWRDKIN 1140
DLVEFPVRNL DLSKFCIGQK EEQLPSYDLY AVINHYGGMI GGHYTACARL PNDRSSQRSD 1200
VGWRLFDDST VTTVDESQVV TRYAYVLFYR RRNSPVERPP RASHSEHHPD LGPAAEAAAS 1260
QGLGPGQAPE VAPTRTAPER FAPPVDRPAP TYSNMEEVD 1299 
Gene Ontology
 GO:0008234; F:cysteine-type peptidase activity; IEA:UniProtKB-KW.
 GO:0004221; F:ubiquitin thiolesterase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro. 
Interpro
 IPR007052; CS-like_domain.
 IPR017447; CS_domain.
 IPR015054; DUF1872.
 IPR008978; HSP20-like_chaperone.
 IPR018200; Pept_C19ubi-hydrolase_C_CS.
 IPR001394; Peptidase_C19.
 IPR002893; Znf_MYND. 
Pfam
 PF04969; CS
 PF08959; DUF1872
 PF00443; UCH
 PF01753; zf-MYND 
SMART
  
PROSITE
 PS51203; CS
 PS00972; UCH_2_1
 PS00973; UCH_2_2
 PS50235; UCH_2_3
 PS01360; ZF_MYND_1
 PS50865; ZF_MYND_2 
PRINTS