UniProt Accession

 MET2B_HUMAN; Q6P1Q9; B4DZ68; Q0IJ54; Q3B7J1 

Genbank Protein ID

 AK002212; AK302775; AC010655; AC090114; BC064929; BC107586; BC121115; BC121116 

Genbank Nucleotide ID

 BAA92136.1; BAG63980.1; AAH64929.1; AAI07587.1; AAI21116.1; AAI21117.1 

Protein Name

 Methyltransferase-like protein 2B 

Protein Synonyms/Alias

  

Gene Name

 METTL2B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
16	APAILADKRQQFGSR	ubiquitination	[1]
66	IQRVCQEKQVDYEIN	acetylation	[2]
76	DYEINAHKYWNDFYK	ubiquitination	[1]
151	SSKSLEHKTQTPPVE	ubiquitination	[3]
283	NRLSRLLKPGGMVLL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Probable S-adenosyl-L-methionine-dependent methyltransferase that mediates 3-methylcytidine modification of some tRNAs. 

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 154 154 Phosphothreonine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Methyltransferase; Phosphoprotein; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 378 AA 

Protein Sequence

Gene Ontology

 GO:0016427; F:tRNA (cytosine) methyltransferase activity; IMP:UniProtKB. 

Interpro

 IPR026113; MeTrfase. 

Pfam

  

SMART

  

PROSITE

  

PRINTS