CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014362
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 148 
Protein Synonyms/Alias
 Beta enolase repressor factor 1; G-rich box-binding protein; Transcription factor BFCOL1; Transcription factor ZBP-89; Zinc finger DNA-binding protein 89 
Gene Name
 Znf148 
Gene Synonyms/Alias
 Zbp89; Zfp148 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
115LNVPISVKQEITFTDsumoylation[1]
342KSDLKKDKNDYLPLYacetylation[2]
356YSSSTKVKDEYMVAEsumoylation[1]
Reference
 [1] Sumoylation-dependent control of homotypic and heterotypic synergy by the Kruppel-type zinc finger protein ZBP-89.
 Chupreta S, Brevig H, Bai L, Merchant JL, Iñiguez-Lluhí JA.
 J Biol Chem. 2007 Dec 14;282(50):36155-66. [PMID: 17940278]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin, stromelysin and enolase. Binds to the G-rich box in the enhancer region of these genes. 
Sequence Annotation
 ZN_FING 171 193 C2H2-type 1.
 ZN_FING 199 221 C2H2-type 2.
 ZN_FING 227 249 C2H2-type 3.
 ZN_FING 255 278 C2H2-type 4.
 MOD_RES 194 194 Phosphothreonine (By similarity).
 MOD_RES 250 250 Phosphoserine (By similarity).
 MOD_RES 305 305 Phosphothreonine.
 MOD_RES 306 306 Phosphoserine.
 MOD_RES 412 412 Phosphoserine (By similarity).
 MOD_RES 607 607 N6-acetyllysine (By similarity).
 MOD_RES 665 665 Phosphoserine (By similarity).
 MOD_RES 784 784 Phosphoserine (By similarity).  
Keyword
 Acetylation; Complete proteome; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 794 AA 
Protein Sequence
MNIDDKLEGL FLKCGGIDEM QSSRAMVVMG GVSGQSAVSG ELQESVLQDR SLPHQEILAA 60
DEVLQESEMR QQDMISHDEL MVHEETVKND EEQMDTHERL PQGLQYALNV PISVKQEITF 120
TDVSEQLMRD KKQVREPVDL QKKKKRKQRS PAKILTINED GSLGLKTPKS HVCEHCNAAF 180
RTNYHLQRHV FIHTGEKPFQ CSQCDMRFIQ KYLLQRHEKI HTGEKPFRCD ECGMRFIQKY 240
HMERHKRTHS GEKPYQCEYC LQYFSRTDRV LKHKRMCHEN HDKKLNRCAI KGGLLTSEED 300
SGFSTSPKDN SLPKKKRQKT EKKSSGMDKE SVLDKSDLKK DKNDYLPLYS SSTKVKDEYM 360
VAEYAVEMPH SSVGGSHLED ASGEIHPPKL VLKKINSKRS LKQPLEQSQT ISPLSSYEDS 420
KVSKYAFELV DKQALLDSEG SADIDQVDNL QEGPSKPVHS STNYDDAMQF LKKKRYLQAA 480
SNNSREYALN VGTIASQPSV TQAAVASVID ESTTASILDS QALNVEIKSN HDKNVIPDEV 540
LQTLLDHYSH KPNGQHEISF SVADTEVTSS ISINSSDVPE VTQSENVGSS SQASSSDKAN 600
MLQEYSKFLQ QALDRTSQND AYLNSPSLNF VTDNQTLPNP PAFSSIDKQV YAAMPINSFR 660
SGMNSPLRTT PDKSHFGLIV GDSQHPFPFS GDETNHASAT STADFLDQVT SQKKAEAQPV 720
HQAYQMSSFE QPFRAPYHGS RAGIATQFST ANGQVNLRGP GTSAEFSEFP LVNVNDNRAG 780
MTSSPDATTG QTFG 794 
Gene Ontology
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003677; F:DNA binding; IDA:MGI.
 GO:0003690; F:double-stranded DNA binding; IEA:Compara.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI.
 GO:0000976; F:transcription regulatory region sequence-specific DNA binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007276; P:gamete generation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0006461; P:protein complex assembly; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS