UniProt Accession

 TAZ_HUMAN; Q16635; A3KQT2; D3DWX2; Q5HY43; Q5HY44; Q5HY45; Q5HY48; Q86XQ6; Q86XQ7; Q86XQ8; Q86XQ9; Q86XR0 

Genbank Protein ID

 X92763; X92764; X92762; AY231461; AY231462; AY231463; AY231464; AY258036; AY258037; AY258038; AY258039; AK291848; BX936347; BX936347; BX936347; BX936347; BX936347; CH471172; CH471172 

Genbank Nucleotide ID

 CAA63419.1; CAA63419.1; CAA63418.1; AAO84335.1; AAO84336.1; AAO84337.1; AAO84338.1; AAO84339.1; AAO84340.1; AAO84341.1; AAO84342.1; BAF84537.1; CAI43207.1; CAI43208.1; CAI43209.1; CAI43211.1; CAM45851.1; EAW72720.1; EAW72728.1 

Protein Name

 Tafazzin 

Protein Synonyms/Alias

 Protein G4.5 

Gene Name

 TAZ 

Gene Synonyms/Alias

 EFE2; G4.5 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
135	FQAENEGKGVLDTGR	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Some isoforms may be involved in cardiolipin (CL) metabolism. 

Sequence Annotation

 REGION 124 194 Hydrophilic.  

Keyword

 Alternative splicing; Cardiomyopathy; Complete proteome; Cytoplasm; Disease mutation; Membrane; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 292 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; TAS:Reactome.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0047184; F:1-acylglycerophosphocholine O-acyltransferase activity; IDA:BHF-UCL.
 GO:0060048; P:cardiac muscle contraction; IMP:BHF-UCL.
 GO:0048738; P:cardiac muscle tissue development; IMP:HGNC.
 GO:0035965; P:cardiolipin acyl-chain remodeling; TAS:Reactome.
 GO:0032049; P:cardiolipin biosynthetic process; IMP:UniProtKB.
 GO:0042407; P:cristae formation; IMP:HGNC.
 GO:0030097; P:hemopoiesis; IMP:HGNC.
 GO:0042775; P:mitochondrial ATP synthesis coupled electron transport; IDA:BHF-UCL.
 GO:0032981; P:mitochondrial respiratory chain complex I assembly; IMP:HGNC.
 GO:0007519; P:skeletal muscle tissue development; IMP:HGNC.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome. 

Interpro

 IPR002123; Plipid/glycerol_acylTrfase.
 IPR000872; Tafazzin. 

Pfam

 PF01553; Acyltransferase 

SMART

 SM00563; PlsC 

PROSITE

  

PRINTS

 PR00979; TAFAZZIN.