UniProt Accession

 LXN_MOUSE; P70202; Q3UDQ0; Q8CCS8 

Genbank Protein ID

 D88769; AK032170; AK149981 

Genbank Nucleotide ID

 BAA13700.1; BAC27739.1; BAE29211.1 

Protein Name

 Latexin 

Protein Synonyms/Alias

 Endogenous carboxypeptidase inhibitor; ECI; Tissue carboxypeptidase inhibitor; TCI 

Gene Name

 Lxn 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
42	QTVQQASKEDIPGRG	acetylation	[1, 2]
55	RGHKYHLKFSVEEII	acetylation	[1]
162	DTWYKMLKIQTVKQV	acetylation	[1]
167	MLKIQTVKQVQRNDD	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 

Functional Description

 Hardly reversible, non-competitive, and potent inhibitor of CPA1, CPA2 and CPA4 (By similarity). May play a role in inflammation. 

Sequence Annotation

 REGION 1 97 Cystatin-like fold 1.
 REGION 98 117 Alpha-helical linker.
 REGION 118 222 Cystatin-like fold 2.
 MOD_RES 55 55 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Heparin-binding; Inflammatory response; Metalloenzyme inhibitor; Metalloprotease inhibitor; Protease inhibitor; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 222 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008201; F:heparin binding; IEA:UniProtKB-KW.
 GO:0008191; F:metalloendopeptidase inhibitor activity; IMP:MGI.
 GO:0050965; P:detection of temperature stimulus involved in sensory perception of pain; IMP:MGI.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW. 

Interpro

 IPR009684; Prot_inh_latexin. 

Pfam

 PF06907; Latexin 

SMART

  

PROSITE

  

PRINTS