| Tag | Content |
|---|
| CPLM ID | CPLM-017389 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Cohesin subunit SA-2 |
Protein Synonyms/Alias | SCC3 homolog 2; Stromal antigen 2 |
Gene Name | STAG2 |
Gene Synonyms/Alias | SA2 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 363 | YNKELNSKLELFTSR | ubiquitination | [1] | | 449 | PEEDGMMKRRGRQGP | ubiquitination | [1] | | 562 | TQLDDRTKITELFAV | ubiquitination | [1] | | 622 | QIRNIVEKHTDTDVL | ubiquitination | [1] | | 664 | LIDELADKFNRLLED | ubiquitination | [1] | | 705 | HNAHDLSKWDLFACN | ubiquitination | [1] | | 714 | DLFACNYKLLKTGIE | ubiquitination | [1] | | 755 | ITESSSTKEDLLRLK | ubiquitination | [1] | | 901 | NDYGDIIKETMSKTR | ubiquitination | [1] | | 949 | SSTFSGIKELARRFA | ubiquitination | [1] | | 965 | TFGLDQLKTREAIAM | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. |
Sequence Annotation | DOMAIN 293 378 SCD.
MOD_RES 1 1 N-acetylmethionine.
MOD_RES 607 607 N6-acetyllysine.
MOD_RES 1058 1058 Phosphoserine.
MOD_RES 1061 1061 Phosphoserine.
MOD_RES 1112 1112 Phosphothreonine.
MOD_RES 1160 1160 Phosphothreonine (By similarity).
MOD_RES 1177 1177 Phosphoserine.
MOD_RES 1178 1178 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition; Complete proteome; Meiosis; Mitosis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1231 AA |
Protein Sequence | MIAAPEIPTD FNLLQESETH FSSDTDFEDI EGKNQKQGKG KTCKKGKKGP AEKGKGGNGG 60
GKPPSGPNRM NGHHQQNGVE NMMLFEVVKM GKSAMQSVVD DWIESYKHDR DIALLDLINF 120
FIQCSGCKGV VTAEMFRHMQ NSEIIRKMTE EFDEDSGDYP LTMAGPQWKK FKSSFCEFIG 180
VLVRQCQYSI IYDEYMMDTV ISLLTGLSDS QVRAFRHTST LAAMKLMTAL VNVALNLSIN 240
MDNTQRQYEA ERNKMIGKRA NERLELLLQK RKELQENQDE IENMMNAIFK GVFVHRYRDA 300
IAEIRAICIE EIGIWMKMYS DAFLNDSYLK YVGWTMHDKQ GEVRLKCLTA LQGLYYNKEL 360
NSKLELFTSR FKDRIVSMTL DKEYDVAVQA IKLLTLVLQS SEEVLTAEDC ENVYHLVYSA 420
HRPVAVAAGE FLYKKLFSRR DPEEDGMMKR RGRQGPNANL VKTLVFFFLE SELHEHAAYL 480
VDSMWDCATE LLKDWECMNS LLLEEPLSGE EALTDRQESA LIEIMLCTIR QAAECHPPVG 540
RGTGKRVLTA KEKKTQLDDR TKITELFAVA LPQLLAKYSV DAEKVTNLLQ LPQYFDLEIY 600
TTGRLEKHLD ALLRQIRNIV EKHTDTDVLE ACSKTYHALC NEEFTIFNRV DISRSQLIDE 660
LADKFNRLLE DFLQEGEEPD EDDAYQVLST LKRITAFHNA HDLSKWDLFA CNYKLLKTGI 720
ENGDMPEQIV IHALQCTHYV ILWQLAKITE SSSTKEDLLR LKKQMRVFCQ ICQHYLTNVN 780
TTVKEQAFTI LCDILMIFSH QIMSGGRDML EPLVYTPDSS LQSELLSFIL DHVFIEQDDD 840
NNSADGQQED EASKIEALHK RRNLLAAFCK LIVYTVVEMN TAADIFKQYM KYYNDYGDII 900
KETMSKTRQI DKIQCAKTLI LSLQQLFNEM IQENGYNFDR SSSTFSGIKE LARRFALTFG 960
LDQLKTREAI AMLHKDGIEF AFKEPNPQGE SHPPLNLAFL DILSEFSSKL LRQDKRTVYV 1020
YLEKFMTFQM SLRREDVWLP LMSYRNSLLA GGDDDTMSVI SGISSRGSTV RSKKSKPSTG 1080
KRKVVEGMQL SLTEESSSSD SMWLSREQTL HTPVMMQTPQ LTSTIMREPK RLRPEDSFMS 1140
VYPMQTEHHQ TPLDYNTQVT WMLAQRQQEE ARQQQERAAM SYVKLRTNLQ HAIRRGTSLM 1200
EDDEEPIVED VMMSSEGRIE DLNEGMDFDT MDIDLPPSKN RRERTELKPD FFDPASIMDE 1260
SVLGVSMF 1268 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |