CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-002022
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heat shock protein 83 
Protein Synonyms/Alias
 HSP 82 
Gene Name
 Hsp83 
Gene Synonyms/Alias
 Hsp82; CG1242 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
29INTFYSNKEIFLRELacetylation[1]
62PSKLDSGKELYIKLIacetylation[1]
67SGKELYIKLIPNKTAacetylation[1]
190TDYLEESKIKEIVNKacetylation[1]
197KIKEIVNKHSQFIGYacetylation[1]
212PIKLLVEKEREKEVSacetylation[1]
268KKKTIKEKYTEDEELacetylation[1]
277TEDEELNKTKPIWTRacetylation[1]
392REMLQQNKVLKVIRKacetylation[1]
395LQQNKVLKVIRKNLVacetylation[1]
428KFYDQFSKNLKLGVHacetylation[1]
443EDSNNRAKLADFLRFacetylation[1]
474SRMKDNQKHVYFITGacetylation[1]
543LPEDESEKKKREEDKacetylation[1]
558AKFESLCKLMKSILDacetylation[1]
561ESLCKLMKSILDNKVacetylation[1]
567MKSILDNKVEKVVVSacetylation[1]
570ILDNKVEKVVVSNRLacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
 Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Together with Hop and piwi, mediates canalization, also known as developmental robustness, likely via epigenetic silencing of existing genetic variants and suppression of transposon-induced new genetic variation. 
Sequence Annotation
 MOTIF 713 717 TPR repeat-binding.
 BINDING 39 39 ATP (By similarity).
 BINDING 81 81 ATP (By similarity).
 BINDING 100 100 ATP (By similarity).
 BINDING 126 126 ATP; via amide nitrogen (By similarity).
 BINDING 385 385 ATP (By similarity).
 MOD_RES 219 219 Phosphoserine.
 MOD_RES 294 294 Phosphotyrosine.  
Keyword
 ATP-binding; Chaperone; Complete proteome; Cytoplasm; Nucleotide-binding; Phosphoprotein; Reference proteome; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 717 AA 
Protein Sequence
MPEEAETFAF QAEIAQLMSL IINTFYSNKE IFLRELISNA SDALDKIRYE SLTDPSKLDS 60
GKELYIKLIP NKTAGTLTII DTGIGMTKSD LVNNLGTIAK SGTKAFMEAL QAGADISMIG 120
QFGVGFYSAY LVADKVTVTS KNNDDEQYVW ESSAGGSFTV RADNSEPLGR GTKIVLYIKE 180
DQTDYLEESK IKEIVNKHSQ FIGYPIKLLV EKEREKEVSD DEADDEKKEG DEKKEMETDE 240
PKIEDVGEDE DADKKDKDAK KKKTIKEKYT EDEELNKTKP IWTRNPDDIS QEEYGEFYKS 300
LTNDWEDHLA VKHFSVEGQL EFRALLFIPR RTPFDLFENQ KKRNNIKLYV RRVFIMDNCE 360
DLIPEYLNFM KGVVDSEDLP LNISREMLQQ NKVLKVIRKN LVKKTMELIE ELTEDKENYK 420
KFYDQFSKNL KLGVHEDSNN RAKLADFLRF HTSASGDDFC SLADYVSRMK DNQKHVYFIT 480
GESKDQVSNS AFVERVKARG FEVVYMTEPI DEYVIQHLKE YKGKQLVSVT KEGLELPEDE 540
SEKKKREEDK AKFESLCKLM KSILDNKVEK VVVSNRLVDS PCCIVTSQFG WSANMERIMK 600
AQALRDTATM GYMAGKKQLE INPDHPIVET LRQKADADKN DKAVKDLVIL LFETSLLSSG 660
FSLDSPQVHA SRIYRMIKLG LGIDEDEPMT TDDAQSAGDA PSLVEDTEDA SHMEEVD 717 
Gene Ontology
 GO:0005813; C:centrosome; IDA:FlyBase.
 GO:0005811; C:lipid particle; IDA:FlyBase.
 GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase.
 GO:0005705; C:polytene chromosome interband; IDA:FlyBase.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0007015; P:actin filament organization; IMP:FlyBase.
 GO:0007098; P:centrosome cycle; IMP:FlyBase.
 GO:0009631; P:cold acclimation; IEP:FlyBase.
 GO:0007052; P:mitotic spindle organization; IMP:FlyBase.
 GO:0010529; P:negative regulation of transposition; IMP:FlyBase.
 GO:0019094; P:pole plasm mRNA localization; IMP:FlyBase.
 GO:0006457; P:protein folding; TAS:FlyBase.
 GO:0008360; P:regulation of cell shape; IMP:FlyBase.
 GO:0045187; P:regulation of circadian sleep/wake cycle, sleep; IMP:FlyBase.
 GO:0009408; P:response to heat; IEP:FlyBase.
 GO:0007283; P:spermatogenesis; IMP:FlyBase.
 GO:0008293; P:torso signaling pathway; NAS:FlyBase. 
Interpro
 IPR003594; HATPase_ATP-bd.
 IPR019805; Heat_shock_protein_90_CS.
 IPR001404; Hsp90.
 IPR020575; Hsp90_N.
 IPR020568; Ribosomal_S5_D2-typ_fold. 
Pfam
 PF02518; HATPase_c
 PF00183; HSP90 
SMART
 SM00387; HATPase_c 
PROSITE
 PS00298; HSP90 
PRINTS
 PR00775; HEATSHOCK90.