UniProt Accession

 MB12B_MOUSE; Q6KAU4; A2ARF1; Q6PB42 

Genbank Protein ID

 AK131113; AL845360; BX649361; BX649361; AL845360; BC049129; BC059907 

Genbank Nucleotide ID

 BAD21363.1; CAM23908.1; CAM23908.1; CAM27811.1; CAM27811.1; AAH49129.2; AAH59907.1 

Protein Name

 Multivesicular body subunit 12B 

Protein Synonyms/Alias

 ESCRT-I complex subunit MVB12B; Protein FAM125B 

Gene Name

 Mvb12b 

Gene Synonyms/Alias

 Fam125b 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
113	GNVLVDMKLIDVKDT	ubiquitination	[1]
288	KSLAEIEKEYEYSFR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity). 

Sequence Annotation

 DOMAIN 45 191 MABP.
 DOMAIN 252 301 UMA.
 MOD_RES 99 99 Phosphoserine (By similarity).
 MOD_RES 120 120 Phosphothreonine (By similarity).
 MOD_RES 202 202 Phosphothreonine (By similarity).
 MOD_RES 203 203 Phosphothreonine (By similarity).
 MOD_RES 307 307 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Endosome; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 317 AA 

Protein Sequence

Gene Ontology

 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR018798; FAM125.
 IPR023341; MABP.
 IPR023340; UMA. 

Pfam

 PF10240; DUF2464 

SMART

  

PROSITE

 PS51498; MABP
 PS51497; UMA 

PRINTS