UniProt Accession

 LYAM1_HUMAN; P14151; B2R6Q8; P15023; Q9UJ43 

Genbank Protein ID

 M25280; X16150; X17519; X17519; X16070; M32414; M32406; M32407; M32408; M32409; M32410; M32411; M32412; M32413; AJ246000; AK312673; AY233976; AL021940; CH471067 

Genbank Nucleotide ID

 AAC63053.1; CAA34275.1; CAB43536.1; CAB43537.1; CAA34203.1; AAB60700.1; AAB60700.1; AAB60700.1; AAB60700.1; AAB60700.1; AAB60700.1; AAB60700.1; AAB60700.1; AAB60700.1; CAB55488.1; BAG35555.1; AAO48272.1; CAI19356.1; EAW90856.1 

Protein Name

 L-selectin 

Protein Synonyms/Alias

 CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; TQ1; gp90-MEL; CD62L 

Gene Name

 SELL 

Gene Synonyms/Alias

 LNHR; LYAM1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
78	AEIEYLEKTLPFSRS	ubiquitination	[1, 2]
93	YYWIGIRKIGGIWTW	ubiquitination	[1]
105	WTWVGTNKSLTEEAE	ubiquitination	[1]
122	GDGEPNNKKNKEDCV	ubiquitination	[3]
123	DGEPNNKKNKEDCVE	ubiquitination	[1]
125	EPNNKKNKEDCVEIY	ubiquitination	[1]
134	DCVEIYIKRNKDAGK	ubiquitination	[1]
137	EIYIKRNKDAGKWND	ubiquitination	[1]
141	KRNKDAGKWNDDACH	ubiquitination	[1]
149	WNDDACHKLKAALCY	ubiquitination	[1]
299	GTELIGKKKTICESS	ubiquitination	[1]
300	TELIGKKKTICESSG	ubiquitination	[1]
321	PICQKLDKSFSMIKE	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia. 

Sequence Annotation

 DOMAIN 55 155 C-type lectin.
 DOMAIN 156 192 EGF-like.
 DOMAIN 195 256 Sushi 1.
 DOMAIN 257 318 Sushi 2.
 CARBOHYD 60 60 N-linked (GlcNAc...).
 CARBOHYD 104 104 N-linked (GlcNAc...).
 CARBOHYD 177 177 N-linked (GlcNAc...) (Potential).
 CARBOHYD 232 232 N-linked (GlcNAc...) (Potential).
 CARBOHYD 246 246 N-linked (GlcNAc...) (Potential).
 CARBOHYD 271 271 N-linked (GlcNAc...) (Potential).
 CARBOHYD 311 311 N-linked (GlcNAc...) (Potential).
 DISULFID 57 155 By similarity.
 DISULFID 128 147 By similarity.
 DISULFID 160 171 By similarity.
 DISULFID 165 180 By similarity.
 DISULFID 182 191 By similarity.
 DISULFID 197 241 By similarity.
 DISULFID 227 254 By similarity.
 DISULFID 259 303 By similarity.
 DISULFID 289 316 By similarity.  

Keyword

 3D-structure; Alternative splicing; Cell adhesion; Complete proteome; Disulfide bond; EGF-like domain; Glycoprotein; Lectin; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Sushi; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 372 AA 

Protein Sequence

Gene Ontology

 GO:0009897; C:external side of plasma membrane; IEA:Compara.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0030246; F:carbohydrate binding; TAS:ProtInc.
 GO:0043208; F:glycosphingolipid binding; TAS:BHF-UCL.
 GO:0008201; F:heparin binding; TAS:BHF-UCL.
 GO:0007596; P:blood coagulation; TAS:Reactome.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0050900; P:leukocyte migration; TAS:Reactome.
 GO:0050776; P:regulation of immune response; TAS:Reactome.
 GO:0033198; P:response to ATP; IEA:Compara. 

Interpro

 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR018378; C-type_lectin_CS.
 IPR016187; C-type_lectin_fold.
 IPR000742; EG-like_dom.
 IPR013032; EGF-like_CS.
 IPR016348; L-selectin.
 IPR002396; Selectin_superfamily.
 IPR000436; Sushi_SCR_CCP. 

Pfam

 PF00008; EGF
 PF00059; Lectin_C
 PF00084; Sushi 

SMART

 SM00032; CCP
 SM00034; CLECT
 SM00181; EGF 

PROSITE

 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2
 PS00022; EGF_1
 PS01186; EGF_2
 PS50026; EGF_3
 PS50923; SUSHI 

PRINTS

 PR00343; SELECTIN.