CPLM-009418

Genbank Nucleotide ID

40S ribosomal protein S7

Protein Synonyms/Alias

Homo sapiens (Human)

Position	Peptide	Type	References
10	SSSAKIVKPNGEKPD	ubiquitination	[1, 2, 3]
15	IVKPNGEKPDEFESG	ubiquitination	[1, 2, 3]
37	LEMNSDLKAQLRELN	ubiquitination	[1, 4]
49	ELNITAAKEIEVGGG	ubiquitination	[1, 3, 4, 5, 6, 7, 8]
58	IEVGGGRKAIIIFVP	ubiquitination	[3]
70	FVPVPQLKSFQKIQV	ubiquitination	[2, 3, 4, 7, 8, 9]
74	PQLKSFQKIQVRLVR	acetylation	[10]
74	PQLKSFQKIQVRLVR	ubiquitination	[1, 2, 3, 4, 7, 8, 9, 11]
85	RLVRELEKKFSGKHV	ubiquitination	[2, 3, 4]
86	LVRELEKKFSGKHVV	ubiquitination	[3]
90	LEKKFSGKHVVFIAQ	ubiquitination	[1, 2, 3]
142	FPSEIVGKRIRVKLD	ubiquitination	[1, 2, 3, 4, 5, 9]
147	VGKRIRVKLDGSRLI	ubiquitination	[3]
155	LDGSRLIKVHLDKAQ	ubiquitination	[2, 3, 7, 8, 11]
160	LIKVHLDKAQQNNVE	ubiquitination	[1, 3, 11]
169	QQNNVEHKVETFSGV	acetylation	[10]
169	QQNNVEHKVETFSGV	ubiquitination	[3, 12, 13]
178	ETFSGVYKKLTGKDV	ubiquitination	[1, 2, 3, 13]
179	TFSGVYKKLTGKDVN	ubiquitination	[3, 13]
183	VYKKLTGKDVNFEFP	ubiquitination	[1, 2, 3, 4, 7, 8, 9, 12, 13]

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
[2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
[3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
[4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
[5] Global analysis of lysine ubiquitination by ubiquitin remnant immunoaffinity profiling.
Xu G, Paige JS, Jaffrey SR.
Nat Biotechnol. 2010 Aug;28(8):868-73. [PMID: 20639865]
[6] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
[7] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
[8] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
Chen Z, Zhou Y, Song J, Zhang Z.
Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
[9] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
[10] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
[11] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
[12] Global identification of modular cullin-RING ligase substrates.
Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
[13] Integrated proteomic analysis of post-translational modifications by serial enrichment.
Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]

Functional Description

Required for rRNA maturation.

MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 74 74 N6-acetyllysine.

3D-structure; Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; Diamond-Blackfan anemia; Direct protein sequencing; Reference proteome; Ribonucleoprotein; Ribosomal protein.

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

GO:0030686; C:90S preribosome; IBA:RefGenome.
GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
GO:0005730; C:nucleolus; IDA:UniProtKB.
GO:0032040; C:small-subunit processome; IBA:RefGenome.
GO:0003723; F:RNA binding; NAS:UniProtKB.
GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
GO:0042274; P:ribosomal small subunit biogenesis; IMP:UniProtKB.
GO:0006364; P:rRNA processing; IMP:UniProtKB.
GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
GO:0006414; P:translational elongation; TAS:Reactome.
GO:0006413; P:translational initiation; TAS:Reactome.
GO:0006415; P:translational termination; TAS:Reactome.
GO:0019083; P:viral transcription; TAS:Reactome.

IPR000554; Ribosomal_S7e.

PF01251; Ribosomal_S7e

PS00948; RIBOSOMAL_S7E