UniProt Accession

 PDLI1_MOUSE; O70400; Q99K93 

Genbank Protein ID

 AF053367; AK076285; AK088089; AK146225; BC004809 

Genbank Nucleotide ID

 AAC08436.1; BAC36288.1; BAC40138.1; BAE26993.1; AAH04809.1 

Protein Name

 PDZ and LIM domain protein 1 

Protein Synonyms/Alias

 C-terminal LIM domain protein 1; Elfin; LIM domain protein CLP-36 

Gene Name

 Pdlim1 

Gene Synonyms/Alias

 Clim1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
22	GFRLVGGKDFEQPLA	acetylation	[1, 2]
71	LEAQNKIKGCADNMT	acetylation	[3]
190	SGSLIIDKDSEVYKM	acetylation	[1]
307	EDQIYCEKHARERVT	acetylation	[3]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton (By similarity). 

Sequence Annotation

 DOMAIN 3 85 PDZ.
 DOMAIN 256 315 LIM zinc-binding.
 METAL 258 258 Zinc 1 (By similarity).
 METAL 261 261 Zinc 1 (By similarity).
 METAL 278 278 Zinc 1 (By similarity).
 METAL 281 281 Zinc 1 (By similarity).
 METAL 284 284 Zinc 2 (By similarity).
 METAL 287 287 Zinc 2 (By similarity).
 METAL 305 305 Zinc 2 (By similarity).
 METAL 308 308 Zinc 2 (By similarity).
 MOD_RES 2 2 N-acetylthreonine (By similarity).
 MOD_RES 90 90 Phosphoserine (By similarity).
 MOD_RES 130 130 Phosphoserine (By similarity).
 MOD_RES 142 142 Phosphotyrosine (By similarity).
 MOD_RES 319 319 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Cytoskeleton; LIM domain; Metal-binding; Phosphoprotein; Reference proteome; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 327 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0003713; F:transcription coactivator activity; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI.
 GO:0001666; P:response to hypoxia; IEA:Compara. 

Interpro

 IPR001478; PDZ.
 IPR001781; Znf_LIM. 

Pfam

 PF00412; LIM
 PF00595; PDZ 

SMART

 SM00132; LIM
 SM00228; PDZ 

PROSITE

 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2
 PS50106; PDZ 

PRINTS