Tag | Content |
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CPLM ID | CPLM-020517 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Charged multivesicular body protein 1b-2 |
Protein Synonyms/Alias | Chromatin-modifying protein 1b-2; CHMP1b-2 |
Gene Name | Chmp1b2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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97 | KSMAGVVKSMDATLR | ubiquitination | [1] | 110 | LRSMNLEKISALMDK | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4. Involved in cytokinesis. Involved in recruiting VPS4A and/or VPS4B and SPAST to the midbody of dividing cells (By similarity). |
Sequence Annotation | REGION 132 156 Interaction with IST1 (By similarity). REGION 174 199 Interaction with SPAST (By similarity). REGION 180 199 Interaction with VTA1 (By similarity). REGION 180 196 Interaction with VPS4A, MITD1 and STAMBP REGION 183 199 Interaction with VPS4B (By similarity). MOTIF 186 196 MIT-interacting motif. |
Keyword | Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 199 AA |
Protein Sequence | MSNMEKHLFN LKFAAKELNR NAKKCDKEEK AEKAKIKKAI QKGNTEVARI HAENAIRQKN 60 QAINFLRMSA RVDAVAARVQ TAVTMGKVTK SMAGVVKSMD ATLRSMNLEK ISALMDKFEH 120 QFETLDVQTQ QMEDTMSSTT TLTTPQNQVD MLLQEMADEA GLDLNMELPQ GQTGSVGASV 180 ASTEQDELSQ RLARLRDQV 199 |
Gene Ontology | |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |