UniProt Accession

 ACTA_MOUSE; P62737; P03996; P04108 

Genbank Protein ID

 X13297; AK017374; BC064800; M57409 

Genbank Nucleotide ID

 CAA31659.1; BAB30715.1; AAH64800.1 

Protein Name

 Actin, aortic smooth muscle 

Protein Synonyms/Alias

 Alpha-actin-2 

Gene Name

 Acta2 

Gene Synonyms/Alias

 Actsa; Actvs 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
293	KCDIDIRKDLYANNV	acetylation	[1]
293	KCDIDIRKDLYANNV	ubiquitination	[2]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. 

Sequence Annotation

 MOD_RES 3 3 N-acetylglutamate.
 MOD_RES 46 46 Methionine sulfoxide (By similarity).
 MOD_RES 75 75 Tele-methylhistidine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Methylation; Muscle protein; Nucleotide-binding; Oxidation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 377 AA 

Protein Sequence

Gene Ontology

 GO:0015629; C:actin cytoskeleton; IDA:MGI.
 GO:0043234; C:protein complex; IEA:Compara.
 GO:0030485; C:smooth muscle contractile fiber; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0072144; P:glomerular mesangial cell development; IEA:Compara.
 GO:0008217; P:regulation of blood pressure; IMP:MGI.
 GO:0009615; P:response to virus; IEA:Compara.
 GO:0014829; P:vascular smooth muscle contraction; IMP:MGI. 

Interpro

 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR004001; Actin_CS. 

Pfam

 PF00022; Actin 

SMART

 SM00268; ACTIN 

PROSITE

 PS00406; ACTINS_1
 PS00432; ACTINS_2
 PS01132; ACTINS_ACT_LIKE 

PRINTS

 PR00190; ACTIN.