CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-001119
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger BED domain-containing protein 4 
Protein Synonyms/Alias
  
Gene Name
 ZBED4 
Gene Synonyms/Alias
 KIAA0637 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
50KSEQEDMKQTDSGGEubiquitination[1]
69GGTGCSCKPPGKYLSubiquitination[2, 3]
141AICMYCVKEFSRGKNubiquitination[2]
147VKEFSRGKNEKDLSTubiquitination[3]
150FSRGKNEKDLSTSCLubiquitination[2, 3]
547DLPTVVTKNNQVMFPubiquitination[2]
559MFPVNSKKTSKLWNHubiquitination[2]
647SFDDTNEKFYDSHPVubiquitination[2, 3]
689NRLLEYLKPQYSLPAubiquitination[2]
869RSPKAKEKLAELQREubiquitination[2]
891LIQDVPSKWSTSFHMubiquitination[2]
986DTMLRSLKEAMVSRLubiquitination[2]
1026EEEAEQYKQDLIRELubiquitination[2]
1056CDAGSPSKDSAAEENubiquitination[2]
1133PSIVPSEKLFNTPTEubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
 ZN_FING 115 172 BED-type 1.
 ZN_FING 285 342 BED-type 2.
 ZN_FING 456 512 BED-type 3.
 ZN_FING 558 615 BED-type 4.  
Keyword
 Complete proteome; Cytoplasm; Metal-binding; Nucleus; Polymorphism; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1171 AA 
Protein Sequence
MENNLKTCPK EDGDFVSDKI KFKIEEEDDD GIPPDSLERM DFKSEQEDMK QTDSGGERAG 60
LGGTGCSCKP PGKYLSAESE DDYGALFSQY SSTLYDVAME AVTQSLLSSR NMSSRKKSPA 120
WKHFFISPRD STKAICMYCV KEFSRGKNEK DLSTSCLMRH VRRAHPTVLI QENGSVSAVS 180
SFPSPSLLLP PQPADAGDLS TILSPIKLVQ KVASKIPSPD RITEESVSVV SSEEISSDMS 240
VSEKCGREEA LVGSSPHLPA LHYDEPAENL AEKSLPLPKS TSGSRRRSAV WKHFYLSPLD 300
NSKAVCIHCM NEFSRGKNGK DLGTSCLIRH MWRAHRAIVL QENGGTGIPP LYSTPPTLLP 360
SLLPPEGELS SVSSSPVKPV RESPSASSSP DRLTEDLQSH LNPGDGLMED VAAFSSSDDI 420
GEASASSPEK QQADGLSPRL FESGAIFQQN KKVMKRLKSE VWHHFSLAPM DSLKAECRYC 480
GCAISRGKKG DVGTSCLMRH LYRRHPEVVG SQKGFLGASL ANSPYATLAS AESSSSKLTD 540
LPTVVTKNNQ VMFPVNSKKT SKLWNHFSIC SADSTKVVCL HCGRTISRGK KPTNLGTSCL 600
LRHLQRFHSN VLKTEVSETA RPSSPDTRVP RGTELSGASS FDDTNEKFYD SHPVAKKITS 660
LIAEMIALDL QPYSFVDNVG FNRLLEYLKP QYSLPAPSYF SRTAIPGMYD NVKQIIMSHL 720
KEAESGVIHF TSGIWMSNQT REYLTLTAHW VSFESPARPR CDDHHCSALL DVSQVDCDYS 780
GNSIQKQLEC WWEAWVTSTG LQVGITVTDN ASIGKTLNEG EHSSVQCFSH TVNLIVSEAI 840
KSQRMVQNLL SLARKICERV HRSPKAKEKL AELQREYALP QHHLIQDVPS KWSTSFHMLE 900
RLIEQKRAIN EMSVECNFRE LISCDQWEVM QSVCRALKPF EAASREMSTQ MSTLSQVIPM 960
VHILNRKVEM LFEETMGIDT MLRSLKEAMV SRLSATLHDP RYVFATLLDP RYKASLFTEE 1020
EAEQYKQDLI RELELMNSTS EDVAASHRCD AGSPSKDSAA EENLWSLVAK VKKKDPREKL 1080
PEAMVLAYLE EEVLEHSCDP LTYWNLKKAS WPGLSALAVR FLGCPPSIVP SEKLFNTPTE 1140
NGSLGQSRLM MEHFEKLIFL KVNLPLIYFQ Y 1171 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR008906; HATC.
 IPR012337; RNaseH-like_dom.
 IPR003656; Znf_BED_prd. 
Pfam
 PF05699; Dimer_Tnp_hAT
 PF02892; zf-BED 
SMART
 SM00614; ZnF_BED 
PROSITE
 PS50808; ZF_BED 
PRINTS