UniProt Accession

 RGS7_RAT; P49803; Q9R0R0 

Genbank Protein ID

 AB024398; U32328 

Genbank Nucleotide ID

 BAA75635.1; AAC52368.1 

Protein Name

 Regulator of G-protein signaling 7 

Protein Synonyms/Alias

 RGS7 

Gene Name

 Rgs7 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
225	SRMRNPHKTRKSVYG	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer (By similarity). May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations. May play a role in synaptic vesicle exocytosis. 

Sequence Annotation

 DOMAIN 37 112 DEP.
 DOMAIN 255 316 G protein gamma.
 DOMAIN 333 448 RGS.
 MOD_RES 229 229 Phosphoserine (By similarity).
 MOD_RES 434 434 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Lipoprotein; Palmitate; Phosphoprotein; Reference proteome; Signal transduction inhibitor. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 477 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0044292; C:dendrite terminus; IEA:Compara.
 GO:0005834; C:heterotrimeric G-protein complex; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0043234; C:protein complex; IDA:RGD.
 GO:0005096; F:GTPase activator activity; IBA:RefGenome.
 GO:0004871; F:signal transducer activity; IEA:InterPro.
 GO:0007186; P:G-protein coupled receptor signaling pathway; IEA:InterPro.
 GO:0035556; P:intracellular signal transduction; IEA:InterPro.
 GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IDA:RGD.
 GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. 

Interpro

 IPR000591; DEP_dom.
 IPR015898; G-protein_gamma-like_dom.
 IPR000342; Regulat_G_prot_signal.
 IPR024066; Regulat_G_prot_signal_dom1.
 IPR016137; Regulat_G_prot_signal_superfam.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00610; DEP
 PF00631; G-gamma
 PF00615; RGS 

SMART

 SM00049; DEP
 SM00224; GGL
 SM00315; RGS 

PROSITE

 PS50186; DEP
 PS50058; G_PROTEIN_GAMMA
 PS50132; RGS 

PRINTS

 PR01301; RGSPROTEIN.