CPLM-000662

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-000662

UniProt Accession

MSH5_HUMAN; O43196; B0V033; B0V034; O60586; Q5BLU9; Q5SSR1; Q8IW44; Q9BQC7

Genbank Protein ID

AF048986; AF048991; AF048988; AF048989; AF048990; AF034759; AF070071; AF070079; AF070072; AF070073; AF070074; AF070075; AF070076; AF070077; AF070078; BT007200; AY943816; BA000025; AF129756; AF134726; AL662834; AL662834; AL662899; AL662899; CR936239; CR925765; CR936239; CR925765; CR759787; CR759787; CR925765; CR936239; CR925765; CR936239; CH471081; CH471081; BC001358; BC002498; BC041031

Genbank Nucleotide ID

AAC62533.1; AAC62534.1; AAC62534.1; AAC62534.1; AAC62534.1; AAB87632.1; AAC70066.1; AAC70067.1; AAC70067.1; AAC70067.1; AAC70067.1; AAC70067.1; AAC70067.1; AAC70067.1; AAC70067.1; AAP35864.1; AAX20111.1; BAB63375.1; AAD18072.1; AAD21822.1; CAI17723.1; CAI17724.1; CAI18423.1; CAI18424.1; CAQ08900.1; CAQ08900.1; CAQ08901.1; CAQ08901.1; CAQ10116.1; CAQ10117.1; CAQ10619.1; CAQ10619.1; CAQ10620.1; CAQ10620.1; EAX03512.1; EAX03514.1; AAH01358.1; AAH02498.1; AAH41031.1

Protein Name

MutS protein homolog 5

Protein Synonyms/Alias

hMSH5

Gene Name

MSH5

Gene Synonyms/Alias

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
105	QSVVTSAKQDENMTR	ubiquitination	[1]
406	IDPEIDEKKRRLMGL	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity).

Sequence Annotation

NP_BIND 592 599 ATP (Potential).

Keyword

Alternative splicing; ATP-binding; Complete proteome; DNA-binding; Meiosis; Nucleotide-binding; Polymorphism; Reference proteome.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

834 AA

Protein Sequence

MASLGANPRR TPQGPRPGAA SSGFPSPAPV PGPREAEEEE VEEEEELAEI HLCVLWNSGY 60
LGIAYYDTSD STIHFMPDAP DHESLKLLQR VLDEINPQSV VTSAKQDENM TRFLGKLASQ 120
EHREPKRPEI IFLPSVDFGL EISKQRLLSG NYSFIPDAMT ATEKILFLSS IIPFDCLLTV 180
RALGGLLKFL GRRRIGVELE DYNVSVPILG FKKFMLTHLV NIDQDTYSVL QIFKSESHPS 240
VYKVASGLKE GLSLFGILNR CHCKWGEKLL RLWFTRPTHD LGELSSRLDV IQFFLLPQNL 300
DMAQMLHRLL GHIKNVPLIL KRMKLSHTKV SDWQVLYKTV YSALGLRDAC RSLPQSIQLF 360
RDIAQEFSDD LHHIASLIGK VVDFEGSLAE NRFTVLPNID PEIDEKKRRL MGLPSFLTEV 420
ARKELENLDS RIPSCSVIYI PLIGFLLSIP RLPSMVEASD FEINGLDFMF LSEEKLHYRS 480
ARTKELDALL GDLHCEIRDQ ETLLMYQLQC QVLARAAVLT RVLDLASRLD VLLALASAAR 540
DYGYSRPRYS PQVLGVRIQN GRHPLMELCA RTFVPNSTEC GGDKGRVKVI TGPNSSGKSI 600
YLKQVGLITF MALVGSFVPA EEAEIGAVDA IFTRIHSCES ISLGLSTFMI DLNQVAKAVN 660
NATAQSLVLI DEFGKGTNTV DGLALLAAVL RHWLARGPTC PHIFVATNFL SLVQLQLLPQ 720
GPLVQYLTME TCEDGNDLVF FYQVCEGVAK ASHASHTAAQ AGLPDKLVAR GKEVSDLIRS 780
GKPIKPVKDL LKKNQMENCQ TLVDKFMKLD LEDPNLDLNV FMSQEVLPAA TSIL 834

Gene Ontology

GO:0000795; C:synaptonemal complex; IBA:RefGenome.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0008094; F:DNA-dependent ATPase activity; IBA:RefGenome.
GO:0030983; F:mismatched DNA binding; IBA:RefGenome.
GO:0051026; P:chiasma assembly; IBA:RefGenome.
GO:0045143; P:homologous chromosome segregation; IBA:RefGenome.
GO:0007136; P:meiotic prophase II; TAS:ProtInc.
GO:0006298; P:mismatch repair; TAS:ProtInc.
GO:0007131; P:reciprocal meiotic recombination; IBA:RefGenome.

Interpro

IPR000432; DNA_mismatch_repair_MutS_C.
IPR007861; DNA_mismatch_repair_MutS_clamp.
IPR007696; DNA_mismatch_repair_MutS_core.
IPR027417; P-loop_NTPase.

Pfam

PF05192; MutS_III
PF05190; MutS_IV
PF00488; MutS_V

SMART

SM00534; MUTSac
SM00533; MUTSd

PROSITE

PS00486; DNA_MISMATCH_REPAIR_2

PRINTS