CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040548
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 ELKS/Rab6-interacting/CAST family member 1 
Protein Synonyms/Alias
  
Gene Name
 Erc1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
10GSARSVGKVEPSSQSacetylation[1, 2]
679EASLLDIKEHASSLAubiquitination[3]
889LMAMEKVKQELESMKubiquitination[3]
898ELESMKAKLSSTQQSubiquitination[3]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1120 AA 
Protein Sequence
MYGSARSVGK VEPSSQSPGR SPRLPRSPRL GHRRTNSTGG SSGNSVGGGS GKTLSMENIQ 60
SLNAAYATSG PMYLSDHENV GAETPKSTMT LGRSGGRLPY GVRMTAMGSS PNIASSGVAS 120
DTIAFGEHHL PPVSMASTVP HSLRQARDNT IMDLQTQLKE VLRENDLLRK DVEVKESKLS 180
SSMNSIKTFW SPELKKERAL RKDEASKITI WKEQYRVVQE ENQHMQMTIQ ALQDELRIQR 240
DLNQLFQQDS SSRTGEPCVA ELTEENFQRL HAEHERQAKE LFLLRKTLEE MELRIETQKQ 300
TLNARDESIK KLLEMLQSKG LSAKATEEDH ERTRRLAEAE MHVHHLESLL EQKEKENNML 360
REEMHRRFEN APDSAKTKAL QTVIEMKDSK ISSMERGLRD LEEEIQMLKS NGALSSEERE 420
EEMKQMEVYR SHSKFMKNKV EQLKEELSSK DAQGEELKKR AAGLQSEIGQ VKQELSRKDT 480
ELLALQTKLE TLTNQFSDSK QHIEVLKESL TAKEQRAAIL QTEVDALRLR LEEKETMLNK 540
KTKQIQDMAE EKGTQAGEIH DLKDMLDVKE RKVNVLQKKI ENLQEQLRDK EKQMSSLKER 600
VKSLQADTTN TDTALTTLEE ALADKERTIE RLKEQRDRDE REKQEEIDTY KKDLKDLREK 660
VSLLQGDLSE KEASLLDIKE HASSLASSGL KKDSRLKTLE IALEQKKEEC LKMESQLKKA 720
HEATLEARAS PEMSDRIQQL EREISRYKDE SSKAQTEVDR LLEILKEVEN EKNDKDKKIA 780
ELESLTSRQV KDQNKKVANL KHKEQVEKKK SAQMLEEARR REDSLSDSSQ QLQDSLRKKD 840
DRIEELEEAL RESVQITAER EMVLAQEESA RTNAEKQVEE LLMAMEKVKQ ELESMKAKLS 900
STQQSLAEKE THLTNLRAER RKHLEEVLEM KQEALLAAIS EKDANIALLE LSSSKKKTQE 960
EVAALKREKD RLVQQLKQQT QNRMKLMADN YEDDHFRSSR SNQTNHKPSP DQIIQPLLEL 1020
DQNRSKLKLY IGHLTALCHD RDPLILRGLT PPASYNADGE QAAWENELQK MTQEQLQNEL 1080
EKVEGDNAEL QEFANTILQQ IADHCPDILE QVVNALEESS 1120 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0008385; C:IkappaB kinase complex; IEA:Compara.
 GO:0017137; F:Rab GTPase binding; IDA:MGI.
 GO:0007252; P:I-kappaB phosphorylation; IEA:Compara.
 GO:0042147; P:retrograde transport, endosome to Golgi; IDA:MGI. 
Interpro
 IPR019323; CAZ_cplx_RIM-bd_prot.
 IPR019018; Rab-bd_FIP-RBD. 
Pfam
 PF10174; Cast
 PF09457; RBD-FIP 
SMART
  
PROSITE
 PS51511; FIP_RBD 
PRINTS