UniProt Accession

 PCID2_HUMAN; Q5JVF3; A6NK09; Q3ZCX1; Q5TC57; Q5TC58; Q9H7K1; Q9HBZ7; Q9NUK6; Q9NVY1; Q9NW44; Q9NWH3 

Genbank Protein ID

 AK000888; AK001185; AK001302; AK002167; AK023313; AK024478; AF183426; AL137002; AL136221; AL137002; AL137002; AL136221; AL136221; AL137002; AL137002; AL136221; AL136221; AL137002; AL137002; AL136221; BC016614; BC031246 

Genbank Nucleotide ID

 BAA91407.1; BAA91542.1; BAA91611.1; BAA92118.1; BAB14521.1; BAB15768.1; AAG09695.1; CAI41391.1; CAI13794.1; CAI13794.1; CAI41378.1; CAI41378.1; CAI13793.1; CAI13793.1; CAI41377.1; CAI41377.1; CAI13792.1; CAI13792.1; CAI41379.1; CAI41379.1; AAH16614.1; AAH31246.1 

Protein Name

 PCI domain-containing protein 2 

Protein Synonyms/Alias

 CSN12-like protein 

Gene Name

 PCID2 

Gene Synonyms/Alias

 HT004 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	CAELVSFKHPHVANP	ubiquitination	[1]
49	QMASPEEKCQQVLEP	ubiquitination	[1]
182	NADQQLVKKGKSKVG	ubiquitination	[1, 2]
187	LVKKGKSKVGDMLEK	ubiquitination	[1]
255	AIDSSNLKDDYSTAQ	ubiquitination	[1, 2, 3]
267	TAQRVTYKYYVGRKA	ubiquitination	[1, 2, 3]
273	YKYYVGRKAMFDSDF	ubiquitination	[1]
442	HQKLVVSKQNPFPPL	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). 

Sequence Annotation

 DOMAIN 277 388 PCI.
 MOD_RES 2 2 N-acetylalanine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 399 AA 

Protein Sequence

Gene Ontology

 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:2000117; P:negative regulation of cysteine-type endopeptidase activity; IMP:UniProtKB.
 GO:0045579; P:positive regulation of B cell differentiation; IEA:Compara.
 GO:0090267; P:positive regulation of mitotic cell cycle spindle assembly checkpoint; IMP:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.
 GO:0043488; P:regulation of mRNA stability; IMP:UniProtKB.
 GO:0048536; P:spleen development; ISS:UniProtKB. 

Interpro

 IPR013143; PAM.
 IPR000717; PCI_dom. 

Pfam

 PF01399; PCI 

SMART

 SM00753; PAM 

PROSITE

  

PRINTS