CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043517
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cirhin 
Protein Synonyms/Alias
  
Gene Name
 CIRH1A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
195KSGSAVHKMIVDRQYubiquitination[1]
207RQYMGVSKRKCIVWGubiquitination[2]
295EKQWVRTKPFQHHTHubiquitination[1]
331VFRPLMEKVEVKNYDubiquitination[1]
335LMEKVEVKNYDAALRubiquitination[1, 2, 3, 4]
343NYDAALRKITFPHRCubiquitination[1, 4]
382GSTVATGKNGDTLPLubiquitination[1, 2, 4, 5]
391GDTLPLSKNADHLLHubiquitination[1]
583DWSRTVQKQGFHHLWubiquitination[1, 2, 3, 4]
631SLPLPNDKTLLYNPFubiquitination[1, 2, 3, 5, 6]
662FKISKIYKPLLFMDLubiquitination[2, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 700 AA 
Protein Sequence
RSTSGAEPES ARARGAGAER GEHREGERGA AGIRCVAYNN QSNRLAVSRT DGTVEIYNLS 60
ANYFQEKFFP GHESRATEAL CWAEGQRLFS AGLNGEIMEY DLQALNIKYA MDAFGGPIWS 120
MAASPSGSQL LVGCEDGSVK LFQITPDKIQ FERNFDRQKS RILSLSWHPS GTHIAAGSID 180
YISVFDVKSG SAVHKMIVDR QYMGVSKRKC IVWGVAFLSD GTIISVDSAG KVQFWDSATG 240
TLVKSHLIAN ADVQSIAVAD QEDSFVVGTA EGTVFHFQLV PVTSNSSEKQ WVRTKPFQHH 300
THDVRTVAHS PTALISGGTD THLVFRPLME KVEVKNYDAA LRKITFPHRC LISCSKKRQL 360
LLFQFAHHLE LWRLGSTVAT GKNGDTLPLS KNADHLLHLK TKGPENIICS CISPCGSWIA 420
YSTVSRFFLY RLNYEHDNIS LKRVSKMPAF LRSALQILFS EDSTKLFVAS NQGALHIVQL 480
SGGSFKHLHA FQPQSGTVEA MCLLAVSPDG NWLAASGTSA GVHVYNVKQL KLHCTVPAYN 540
FPVTAMAIAP NTNNLVIAHS DQQVFEYSIP DKQYTDWSRT VQKQGFHHLW LQRDTPITHI 600
SFHPKRPMHI LLHDAYMFCI IDKSLPLPND KTLLYNPFPP TNESDVIRRR TAHAFKISKI 660
YKPLLFMDLL DERTLVAVER PLDDIIAQLP PPIKKKKFGT 700 
Gene Ontology
  
Interpro
 IPR011047; Quinonprotein_ADH-like_supfam.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50294; WD_REPEATS_REGION 
PRINTS