Tag | Content |
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CPLM ID | CPLM-014860 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Calcyclin-binding protein |
Protein Synonyms/Alias | CacyBP |
Gene Name | Cacybp |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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86 | YGWDQSDKFVKIYIT | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1) (By similarity). |
Sequence Annotation | DOMAIN 74 168 CS. DOMAIN 169 229 SGS. REGION 2 81 Interaction with SIAH1 (By similarity). REGION 74 229 Interaction with SKP1 (By similarity). REGION 155 229 Interaction with S100A6 (By similarity). MOD_RES 2 2 N-acetylalanine (By similarity). MOD_RES 10 10 N6-acetyllysine (By similarity). MOD_RES 21 21 N6-acetyllysine (By similarity). MOD_RES 86 86 N6-acetyllysine (By similarity). MOD_RES 119 119 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation pathway. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 229 AA |
Protein Sequence | MASALEELQK DLEEVKVLLE KSTRKRLRDT LTNEKSKIET ELRNKMQQKS QKKPEFDNEK 60 PAAVVAPLTT GYTVKISNYG WDQSDKFVKI YITLTGVHQV PAENVQVHFT ERSFDLLVKN 120 LNGKNYSMIV NNLLKPISVE SSSKKVKTDT VIILCRKKAE NTRWDYLTQV EKECKEKEKP 180 SYDTEADPSE GLMNVLKKIY EDGDDDMKRT INKAWVESRE KQAREDTEF 229 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |