CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038363
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin-protein ligase UBR5 
Protein Synonyms/Alias
  
Gene Name
 Ubr5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
346GESNPDKKNTPVQSPubiquitination[1]
1109LRELLSAKDARGMTPubiquitination[1]
1351MFGSQENKDPLSASSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Ligase; Reference proteome; Ubl conjugation pathway. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2798 AA 
Protein Sequence
MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ CVVGPNHAAF 60
LLEDGRICRI GFSVQPDRLE LGKPDNNDGS KLNSSSGTGR TSRPGRTSDS PWFLSGSETL 120
GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG ARDSRRQTRV IRTGRDRGSG LLGSQPQPVI 180
PASVIPEELI SQAQVVLQGK SRSVIIRELQ RTNLDVNLAV NNLLSRDDED GDDGDDTASE 240
SYLPGEDLMS LLDADIHSAH PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRVLLLP 300
LERDSELLRE RESVLRLRER RWLDGASFDN ERGSTSKEGE SNPDKKNTPV QSPVSLGEDL 360
QWWPDKDGTK FTCIGALYSE LLAVSSKGEL YQWKWSESEP YRNAQNPSLH HPRATFLGLT 420
NEKIVLLSAN SIRATVATEN NKVATWVDET LSSVASKLEH TAQTYSELQG ERIVSLHCCA 480
LYTCAQLENN LYWWGVVPFS QRKKMLEKAR AKNKKPKSSA GISSMPNITV GTQVCLRNNP 540
LYHAGAVAFS ISAGIPKVGV LMESVWNMND SCRFQLRSPE SLKSMEKASK TLETKPESKQ 600
EPVKTEMGPP PSPASTCSDA SSIASSASMP YKRRRSTPAP REEEKVNEEQ WPLREVVFVE 660
DVKNVPVGKV LKVDGAYVAV KFPGTSTNTT CQNSSGPDAD PSSLLQDCRL LRIDELQVVK 720
TGGTPKVPDC FQRTPKKLCI PEKTEILAVN VDSKGVHAVL KTGSWVRYCV FDLATGKAEQ 780
ENNFPTSSVA FLGQDERSVA IFTAGQESPI VLRDGNGTIY PMAKDCMGGI RDPDWLDLPP 840
ISSLGMGVHS LINLPANSTI KKKAAIIIMA VEKQTLMQHI LRCDYEACRQ YLVNLEQAVV 900
LEQNLQMLQT FISHRCDGNR NILHACVSVC FPTSNKETKE EEEAERSERN TFAERLSAVE 960
AIANAISVVS SNGPGNRAGS SNSRSLRLRE MMRRSLRAAG LGRHEAGASS SDHQDPVSPP 1020
IAPPSWVPDP PSMDPDGDID FILAPAVGSL TTAATGSGQG PSTSTIPGPS TEPSVVESKD 1080
RKANAHFILK LLCDSAVLQP YLRELLSAKD ARGMTPFMSA VSGRAYPAAI TILETAQKIA 1140
KAEVSASEKE EDVFMGMVCP SGTNPDDSPL YVLCCNDTCS FTWTGAEHIN QDIFECRTCG 1200
LLESLCCCTE CARVCHKGHD CKLKRTSPTA YCDCWEKCKC KTLIAGQKSA RLDLLYRLLT 1260
ATNLVTLPNS RGEHLLLFLV QTVARQTVEH CQYRPPRIRE DRNRKTASPE DSDMPDHDLE 1320
PPRFAQLALE RVLQDWNALR SMIMFGSQEN KDPLSASSRI GHLLPEEQVY LNQQSGTIRL 1380
DCFTHCLIVK CTADILLLDT LLGTLVKELQ NKYTPGRREE AIAVTMRFLR SVARVFVILS 1440
VEMASSKKKN NFIPQPIGKC KRVFQALLPY AVEELCNVAE SLIVPVRMGI ARPTAPFTLA 1500
STSIDAMQGS EELFSVEPLP PRPSSDQASS SSQSQSSYII RNPQQRRISQ SQPVRGRDEE 1560
QDDIVSADVE EVEVVEGVAG EEDHHDEQEE HGEENAEAEG HHDEHDEDGS DMELDLLAAA 1620
ETESDSESNH SNQDNASGRR SVVTAATAGS EAGASSVPAF FSEDDSQSND SSDSDSSSSQ 1680
SDDIEQETFM LDEPLERTTN SSHANGAAQA PRSMQWAVRN PQHQRAASTA PSSTSTPAAS 1740
SAGLIYIDPS NLRRSGTIST SAAAAAAALE ASNASSYLTS ASSLARAYSI VIRQISDLMG 1800
LIPKYNHLVY SQIPAAVKLT YQDAVNLQNY VEEKLIPTWN WMVSVMDSTE AQLRYGSALA 1860
SAGDPGHPNH PLHASQNSAR RERMTAREEA SLRTLEGRRR ATLLSARQGM MSARGDFLNY 1920
ALSLMRSHND EHSDVLPVLD VCSLKHVAYV FQALIYWIKA MNQQTTLDTP QLERKRTREL 1980
LELGIDNEDS EHENDDDTSQ SATLNDKDDD SLPAETGQNH PFFRRSDSMT FLGCIPPNPF 2040
EVPLAEAIPL ADQPHLLQPN ARKEDLFGRP SQGLYSSSAG SGKCIVEVTM DRNCLEVLPT 2100
KMSYAANLKN VMNMQNRQKK EGEEQSLLAE EADSSKPGPS APDVAAQLKS SLLAEIGLTE 2160
SEGPPLTSFR PQCSFMGMVI SHDMLLGRWR LSLELFGRVF MEDVGAEPGS ILTELGGFEV 2220
KESKFRREME KLRNQQSRDL SLEVDRDRDL LIQQTMRQLN NHFGRRCATT PMAVHRVKVT 2280
FKDEPGEGSG VARSFYTAIA QAFLSNEKLP NLDCIQNANK GTHTSLMQRL RNRGERDRER 2340
EREREMRRSS GLRAGSRRDR DRDFRRQLSI DTRPFRPASE GNPSDDPDPL PAHRQALGER 2400
LYPRVQAMQP AFASKITGML LELSPAQLLL LLASEDSLRA RVDEAMELII AHGRENGADS 2460
ILDLGLLDSS EKVQENRKRH GSSRSVVDMD LEDTDDGDDN APLFYQPGKR GFYTPRPGKN 2520
TEARLNCFRN IGRILGLCLL QNELCPITLN RHVIKVLLGR KVNWHDFAFF DPVMYESLRQ 2580
LILASQSSDA DAVFSAMDLA FAIDLCKEEG GGQVELIPNG VNIPVTPQNV YEYVRKYAEH 2640
RMLVVAEQPL HAMRKGLLDV LPKNSLEDLT AEDFRLLVNG CGEVNVQMLI SFTSFNDESG 2700
ENAEKLLQFK RWFWSIVEKM SMTERQDLVY FWTSSPSLPA SEEGFQPMPS ITIRPPDDQH 2760
LPTANTCISR LYVPLYSSKQ ILKQKLLLAI KTKNFGFV 2798 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005634; C:nucleus; IBA:RefGenome.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome.
 GO:0034450; F:ubiquitin-ubiquitin ligase activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:2000780; P:negative regulation of double-strand break repair; IEA:Compara.
 GO:1901315; P:negative regulation of histone H2A K63-linked ubiquitination; IEA:Compara.
 GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0035413; P:positive regulation of catenin import into nucleus; IEA:Compara.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IEA:Compara.
 GO:0050847; P:progesterone receptor signaling pathway; IBA:RefGenome.
 GO:0000209; P:protein polyubiquitination; IEA:Compara.
 GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.
 GO:0006974; P:response to DNA damage stimulus; IEA:Compara. 
Interpro
 IPR024725; E3_UbLigase_EDD_UBA.
 IPR000569; HECT.
 IPR002004; PABP_HYD.
 IPR009091; RCC1/BLIP-II.
 IPR003126; Znf_N-recognin.
 IPR013993; Znf_N-recognin_met. 
Pfam
 PF11547; E3_UbLigase_EDD
 PF00632; HECT
 PF00658; PABP
 PF02207; zf-UBR 
SMART
 SM00119; HECTc
 SM00517; PolyA
 SM00396; ZnF_UBR1 
PROSITE
 PS50237; HECT
 PS51309; PABC
 PS51157; ZF_UBR 
PRINTS