| Tag | Content |
|---|
| CPLM ID | CPLM-023253 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-binding cassette sub-family G member 2 |
Protein Synonyms/Alias | Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; CD338 |
Gene Name | ABCG2 |
Gene Synonyms/Alias | ABCP; BCRP; BCRP1; MXR |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 177 | LDKVADSKVGTQFIR | ubiquitination | [1] | | 314 | LNREEDFKATEIIEP | ubiquitination | [1] | | 323 | TEIIEPSKQDKPLIE | ubiquitination | [1] | | 343 | YVNSSFYKETKAELH | ubiquitination | [1] | | 346 | SSFYKETKAELHQLS | ubiquitination | [1] | | 357 | HQLSGGEKKKKITVF | ubiquitination | [1] | | 365 | KKKITVFKEISYTTS | ubiquitination | [1] |
|
Reference | [1] Global identification of modular cullin-RING ligase substrates. Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ. Cell. 2011 Oct 14;147(2):459-74. [ PMID: 21963094] |
Functional Description | Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123. |
Sequence Annotation | DOMAIN 37 286 ABC transporter.
DOMAIN 389 651 ABC transmembrane type-2.
NP_BIND 80 87 ATP (Potential).
CARBOHYD 596 596 N-linked (GlcNAc...).
DISULFID 592 608
DISULFID 603 603 Interchain. |
Keyword | Alternative splicing; ATP-binding; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Membrane; Nucleotide-binding; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 655 AA |
Protein Sequence | MSSSNVEVFI PVSQGNTNGF PATASNDLKA FTEGAVLSFH NICYRVKLKS GFLPCRKPVE 60
KEILSNINGI MKPGLNAILG PTGGGKSSLL DVLAARKDPS GLSGDVLING APRPANFKCN 120
SGYVVQDDVV MGTLTVRENL QFSAALRLAT TMTNHEKNER INRVIQELGL DKVADSKVGT 180
QFIRGVSGGE RKRTSIGMEL ITDPSILFLD EPTTGLDSST ANAVLLLLKR MSKQGRTIIF 240
SIHQPRYSIF KLFDSLTLLA SGRLMFHGPA QEALGYFESA GYHCEAYNNP ADFFLDIING 300
DSTAVALNRE EDFKATEIIE PSKQDKPLIE KLAEIYVNSS FYKETKAELH QLSGGEKKKK 360
ITVFKEISYT TSFCHQLRWV SKRSFKNLLG NPQASIAQII VTVVLGLVIG AIYFGLKNDS 420
TGIQNRAGVL FFLTTNQCFS SVSAVELFVV EKKLFIHEYI SGYYRVSSYF LGKLLSDLLP 480
MRMLPSIIFT CIVYFMLGLK PKADAFFVMM FTLMMVAYSA SSMALAIAAG QSVVSVATLL 540
MTICFVFMMI FSGLLVNLTT IASWLSWLQY FSIPRYGFTA LQHNEFLGQN FCPGLNATGN 600
NPCNYATCTG EEYLVKQGID LSPWGLWKNH VALACMIVIF LTIAYLKLLF LKKYS 655 |
Gene Ontology | GO:0016021; C:integral to membrane; TAS:ProtInc. GO:0005886; C:plasma membrane; TAS:Reactome. GO:0005524; F:ATP binding; TAS:ProtInc. GO:0015232; F:heme transporter activity; TAS:Reactome. GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL. GO:0008559; F:xenobiotic-transporting ATPase activity; TAS:ProtInc. GO:0006879; P:cellular iron ion homeostasis; TAS:Reactome. GO:0046415; P:urate metabolic process; IMP:UniProtKB. |
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Pfam | |
SMART | |
PROSITE | |
PRINTS | |