CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019477
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Janus kinase and microtubule-interacting protein 1 
Protein Synonyms/Alias
 GABA-B receptor-binding protein; Multiple alpha-helices and RNA-linker protein 1; Marlin-1 
Gene Name
 JAKMIP1 
Gene Synonyms/Alias
 GABABRBP; JAMIP1; MARLIN1 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
251DEQLVQVKEAERHHSubiquitination[1]
378LSAQASLKRHTSLNDubiquitination[1]
546LEKLLVEKGQDSKWVubiquitination[1]
551VEKGQDSKWVEEKQLubiquitination[1]
556DSKWVEEKQLLIRTNubiquitination[1]
569TNQDLLEKIYRLEMEubiquitination[1]
610VRDSICCKLSNGADIubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Associates with microtubules and may play a role in the microtubule-dependent transport of the GABA-B receptor. May play a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. 
Sequence Annotation
 REGION 1 365 Mediates association with microtubules.
 REGION 365 626 Mediates interaction with TYK2 and
 MOD_RES 382 382 Phosphoserine.
 MOD_RES 470 470 Phosphothreonine.  
Keyword
 Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Membrane; Microtubule; Phosphoprotein; Polymorphism; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 626 AA 
Protein Sequence
MSKKGRSKGE KPEMETDAVQ MANEELRAKL TSIQIEFQQE KSKVGKLRER LQEAKLEREQ 60
EQRRHTAYIS ELKAKLHEEK TKELQALREG LIRQHEQEAA RTAKIKEGEL QRLQATLNVL 120
RDGAADKVKT ALLTEAREEA RRAFDGERLR LQQEILELKA ARKQAEEALS NCMQADKTKA 180
ADLRAAYQAH QDEVHRIKRE CERDIRRLMD EIKGKDRVIL ALEKELGVQA GQTQKLLLQK 240
EALDEQLVQV KEAERHHSSP KRELPPGIGD MVELMGVQDQ HMDERDVRRF QLKIAELNSV 300
IRKLEDRNTL LADERNELLK RSRETEVQLK PLVEKNKRMN KKNEDLLQSI QRMEEKIKNL 360
TRENVEMKEK LSAQASLKRH TSLNDLSLTR DEQEIEFLRL QVLEQQHVID DLSLERERLL 420
RSKRHRGKSL KPPKKHVVET FFGFDEESVD SETLSETSYN TDRTDRTPAT PEEDLDDATA 480
REEADLRFCQ LTREYQALQR AYALLQEQVG GTLDAEREAR TREQLQADLL RCQAKIEDLE 540
KLLVEKGQDS KWVEEKQLLI RTNQDLLEKI YRLEMEENQL KNEMQDAKDQ NELLEFRVLE 600
LEVRDSICCK LSNGADILFE PKLKFM 626 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
 GO:0019898; C:extrinsic to membrane; IDA:MGI.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0030529; C:ribonucleoprotein complex; IDA:MGI.
 GO:0050811; F:GABA receptor binding; IDA:MGI.
 GO:0003723; F:RNA binding; IDA:MGI.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 
Interpro
 IPR024836; JAKMIP. 
Pfam
  
SMART
  
PROSITE
  
PRINTS