CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-034390
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Peroxiredoxin-2 
Protein Synonyms/Alias
  
Gene Name
 Prdx2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
26AVVDGAFKEIKLSDYacetylation[1]
26AVVDGAFKEIKLSDYubiquitination[2]
29DGAFKEIKLSDYRGKubiquitination[2]
92AWINTPRKEGGLGPLubiquitination[2]
119SQNYGVLKNDEGIAYacetylation[1]
119SQNYGVLKNDEGIAYubiquitination[2]
135GLFIIDAKGVLRQITubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 147 AA 
Protein Sequence
MASGNAQIGK SAPDFTATAV VDGAFKEIKL SDYRGKYVVL FFYPLDFTFV CPTEIIAFSD 60
HAEDFRKLGC EVLGVSVDSQ FTHLAWINTP RKEGGLGPLN IPLLADVTKS LSQNYGVLKN 120
DEGIAYRGLF IIDAKGVLRQ ITVNDLP 147 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0008430; F:selenium binding; TAS:MGI.
 GO:0008379; F:thioredoxin peroxidase activity; ISS:MGI.
 GO:0000187; P:activation of MAPK activity; IMP:MGI.
 GO:0048872; P:homeostasis of number of cells; IMP:MGI.
 GO:0042744; P:hydrogen peroxide catabolic process; IMP:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IDA:MGI.
 GO:0031665; P:negative regulation of lipopolysaccharide-mediated signaling pathway; IMP:MGI.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:MGI.
 GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:MGI.
 GO:0045581; P:negative regulation of T cell differentiation; IMP:MGI.
 GO:0010310; P:regulation of hydrogen peroxide metabolic process; IMP:MGI.
 GO:0002536; P:respiratory burst involved in inflammatory response; IMP:MGI.
 GO:0032496; P:response to lipopolysaccharide; IMP:MGI.
 GO:0042098; P:T cell proliferation; IMP:MGI.
 GO:0048538; P:thymus development; IMP:MGI. 
Interpro
 IPR000866; AhpC/TSA.
 IPR024706; Peroxiredoxin_AhpC-typ.
 IPR012336; Thioredoxin-like_fold. 
Pfam
 PF00578; AhpC-TSA 
SMART
  
PROSITE
 PS51352; THIOREDOXIN_2 
PRINTS