UniProt Accession

 F16P1_RAT; P19112; Q64594 

Genbank Protein ID

 J04112; M57284; M57274; M57279; M57278; M57282; M57281; M86240; BC078894; BC078895 

Genbank Nucleotide ID

 AAA60739.1; AAA41131.1; AAA41131.1; AAA41131.1; AAA41131.1; AAA41131.1; AAA41131.1; AAA86425.1; AAH78894.1; AAH78895.1 

Protein Name

 Fructose-1,6-bisphosphatase 1 

Protein Synonyms/Alias

 FBPase 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 

Gene Name

 Fbp1 

Gene Synonyms/Alias

 Fbp 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
269	IFLYPANKKNPSGKL	acetylation	[1]
275	NKKNPSGKLRLLYEC	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

  

Sequence Annotation

 NP_BIND 18 22 AMP (By similarity).
 NP_BIND 28 32 AMP (By similarity).
 NP_BIND 113 114 AMP (By similarity).
 REGION 122 125 Substrate binding (By similarity).
 REGION 213 216 Substrate binding (By similarity).
 REGION 244 249 Substrate binding (By similarity).
 REGION 275 277 Substrate binding (By similarity).
 METAL 69 69 Magnesium 1 (By similarity).
 METAL 98 98 Magnesium 1 (By similarity).
 METAL 98 98 Magnesium 2 (By similarity).
 METAL 119 119 Magnesium 2 (By similarity).
 METAL 119 119 Magnesium 3 (By similarity).
 METAL 121 121 Magnesium 2; via carbonyl oxygen (By
 METAL 122 122 Magnesium 3 (By similarity).
 METAL 281 281 Magnesium 3 (By similarity).
 BINDING 141 141 AMP (By similarity).
 BINDING 265 265 Substrate (By similarity).
 MOD_RES 2 2 N-acetylvaline.  

Keyword

 Acetylation; Allosteric enzyme; Carbohydrate metabolism; Complete proteome; Direct protein sequencing; Gluconeogenesis; Hydrolase; Magnesium; Metal-binding; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 363 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0016208; F:AMP binding; ISS:UniProtKB.
 GO:0042132; F:fructose 1,6-bisphosphate 1-phosphatase activity; IDA:RGD.
 GO:0046872; F:metal ion binding; ISS:UniProtKB.
 GO:0048029; F:monosaccharide binding; IDA:RGD.
 GO:0035690; P:cellular response to drug; ISS:UniProtKB.
 GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.
 GO:0071286; P:cellular response to magnesium ion; ISS:UniProtKB.
 GO:0006002; P:fructose 6-phosphate metabolic process; ISS:UniProtKB.
 GO:0006094; P:gluconeogenesis; IDA:RGD.
 GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
 GO:0045820; P:negative regulation of glycolysis; ISS:UniProtKB.
 GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:UniProtKB.
 GO:0051289; P:protein homotetramerization; ISS:UniProtKB.
 GO:0006111; P:regulation of gluconeogenesis; ISS:UniProtKB. 

Interpro

 IPR000146; FBPase_class-1/SBPase.
 IPR020548; Fructose_bisphosphatase_AS. 

Pfam

 PF00316; FBPase 

SMART

  

PROSITE

 PS00124; FBPASE 

PRINTS

 PR00115; F16BPHPHTASE.