CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005786
UniProt Accession
Genbank Protein ID
 M69246 
Genbank Nucleotide ID
Protein Name
 Serpin H1 
Protein Synonyms/Alias
 47 kDa heat shock protein; Collagen-binding protein; Colligin; GP46 
Gene Name
 Serpinh1 
Gene Synonyms/Alias
 Cbp1; Hsp47 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
216WDEKFHHKMVDNRGFacetylation[1]
286RLEKLLTKEQLKTWMacetylation[1]
290LLTKEQLKTWMGKMQacetylation[1]
318EVTHDLQKHLAGLGLacetylation[1]
412LVRPKGDKMRDEL**acetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. 
Sequence Annotation
 MOTIF 414 417 Prevents secretion from ER (Probable).
 CARBOHYD 119 119 N-linked (GlcNAc...) (Potential).
 CARBOHYD 124 124 N-linked (GlcNAc...) (Potential).
 CARBOHYD 394 394 N-linked (GlcNAc...) (Potential).  
Keyword
 Chaperone; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycoprotein; Reference proteome; Signal; Stress response. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 417 AA 
Protein Sequence
MRSLLLGTLC LLAVALAAEV KKPVEAAAPG TAEKLSSKAT TLAERSTGLA FSLYQAMAKD 60
QAVENILLSP LVVASSLGLV SLGGKATTAS QAKAVLSAEK LRDEEVHTGL GELVRSLSNS 120
TARNVTWKLG SRLYGPSSVS FADDFVRSSK QHYNCEHSKI NFRDKRSALQ SINEWASQTT 180
DGKLPEVTKD VERTDGALLV NAMFFKPHWD EKFHHKMVDN RGFMVTRSYT VGVTMMHRTG 240
LYNYYDDEKE KLQLVEMPLA HKLSSLIILM PHHVEPLERL EKLLTKEQLK TWMGKMQKKA 300
VAISLPKGVV EVTHDLQKHL AGLGLTEAID KNKADLSRMS GKKDLYLASV FHATAFEWDT 360
EGNPFDQDIY GREELRSPKL FYADHPFIFL VRDNQSGSLL FIGRLVRPKG DKMRDEL 417 
Gene Ontology
 GO:0005737; C:cytoplasm; IBA:RefGenome.
 GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProtKB-SubCell.
 GO:0005518; F:collagen binding; TAS:RGD.
 GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:RefGenome.
 GO:0030162; P:regulation of proteolysis; IBA:RefGenome.
 GO:0006950; P:response to stress; IEA:UniProtKB-KW. 
Interpro
 IPR023795; Protease_inhib_I4_serpin_CS.
 IPR023796; Serpin_dom.
 IPR000215; Serpin_fam. 
Pfam
 PF00079; Serpin 
SMART
 SM00093; SERPIN 
PROSITE
 PS00014; ER_TARGET
 PS00284; SERPIN 
PRINTS