Tag | Content |
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CPLM ID | CPLM-011233 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tyrosine-protein kinase Yes |
Protein Synonyms/Alias | Proto-oncogene c-Yes; p61-Yes |
Gene Name | Yes1 |
Gene Synonyms/Alias | Yes |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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15 | ENKSPAIKYTPENLT | ubiquitination | [1] | 189 | VRESETTKGAYSLSI | ubiquitination | [1] | 233 | AQFDTLQKLVKHYTE | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis (By similarity). |
Sequence Annotation | DOMAIN 89 150 SH3. DOMAIN 156 253 SH2. DOMAIN 275 528 Protein kinase. NP_BIND 281 289 ATP (By similarity). ACT_SITE 394 394 Proton acceptor (By similarity). BINDING 303 303 ATP (By similarity). MOD_RES 11 11 Phosphoserine (By similarity). MOD_RES 26 26 Phosphoserine (By similarity). MOD_RES 32 32 Phosphotyrosine (By similarity). MOD_RES 109 109 Phosphoserine (By similarity). MOD_RES 192 192 Phosphotyrosine. MOD_RES 193 193 Phosphoserine (By similarity). MOD_RES 220 220 Phosphotyrosine. MOD_RES 221 221 Phosphotyrosine (By similarity). MOD_RES 334 334 Phosphotyrosine (By similarity). MOD_RES 343 343 Phosphotyrosine (By similarity). MOD_RES 424 424 Phosphotyrosine; by autocatalysis (By MOD_RES 444 444 Phosphotyrosine (By similarity). MOD_RES 535 535 Phosphotyrosine; by CSK (By similarity). LIPID 2 2 N-myristoyl glycine (By similarity). LIPID 3 3 S-palmitoyl cysteine; in membrane form |
Keyword | 3D-structure; ATP-binding; Cell membrane; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Lipoprotein; Membrane; Myristate; Nucleotide-binding; Palmitate; Phosphoprotein; Proto-oncogene; Reference proteome; SH2 domain; SH3 domain; Transferase; Tyrosine-protein kinase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 541 AA |
Protein Sequence | MGCIKSKENK SPAIKYTPEN LTEPVSPSAS HYGVEHATVA PTSSTKGASV NFNSLSMTPF 60 GGSSGVTPFG GASSSFSVVS SSYPTGLTGG VTIFVALYDY EARTTEDLSF KKGERFQIIN 120 NTEGDWWEAR SIATGKSGYI PSNYVVPADS IQAEEWYFGK MGRKDAERLL LNPGNQRGIF 180 LVRESETTKG AYSLSIRDWD EVRGDNVKHY KIRKLDNGGY YITTRAQFDT LQKLVKHYTE 240 HADGLCHKLT TVCPTVKPQT QGLAKDAWEI PRESLRLEVK LGQGCFGEVW MGTWNGTTKV 300 AIKTLKPGTM MPEAFLQEAQ IMKKLRHDKL VPLYAVVSEE PIYIVTEFMS KGSLLDFLKE 360 GDGKYLKLPQ LVDMAAQIAD GMAYIERMNY IHRDLRAANI LVGENLICKI ADFGLARLIE 420 DNEYTARQGA KFPIKWTAPE AALYGRFTIK SDVWSFGILQ TELVTKGRVP YPGMVNREVL 480 EQVERGYRMP CPQGCPESLH ELMNLCWKKD PDERPTFEYI QSFLEDYFTA TEPQYQPGEN 540 L 541 |
Gene Ontology | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. GO:0005794; C:Golgi apparatus; IEA:Compara. GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. GO:0015758; P:glucose transport; IDA:MGI. GO:0046777; P:protein autophosphorylation; IEA:Compara. |
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