CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015021
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-alpha-acetyltransferase 16, NatA auxiliary subunit 
Protein Synonyms/Alias
 NMDA receptor-regulated 1-like protein; NARG1-like protein 
Gene Name
 NAA16 
Gene Synonyms/Alias
 NARG1L; NAT2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
52HGETLAMKGLTLNCLubiquitination[1, 2]
62TLNCLGKKEEAYEFVubiquitination[2]
94GLLQRSDKKYDEAIKubiquitination[2]
95LLQRSDKKYDEAIKCubiquitination[2]
108KCYRNALKLDKDNLQubiquitination[2]
111RNALKLDKDNLQILRubiquitination[2]
241LLKLGRLKEASEVFKubiquitination[2]
285QIYEEISKQHPKAITubiquitination[2]
320FLRVNFSKGCPPLFTubiquitination[2]
447ADRFINSKCAKYMLRubiquitination[3]
467EAEEMCSKFTREGTSubiquitination[2, 3]
578NPLTNESKQQEINSEubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May belong to a complex displaying N-terminal acetyltransferase activity (By similarity). 
Sequence Annotation
 REPEAT 46 79 TPR 1.
 REPEAT 80 113 TPR 2.
 REPEAT 148 184 TPR 3.
 REPEAT 224 257 TPR 4.
 REPEAT 374 407 TPR 5.
 REPEAT 409 441 TPR 6.
 REPEAT 485 518 TPR 7.  
Keyword
 Alternative splicing; Complete proteome; Polymorphism; Reference proteome; Repeat; TPR repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 864 AA 
Protein Sequence
MPNVLLPPKE SNLFKRILKC YEQKQYKNGL KFCKMILSNP KFAEHGETLA MKGLTLNCLG 60
KKEEAYEFVR KGLRNDVKSH VCWHVYGLLQ RSDKKYDEAI KCYRNALKLD KDNLQILRDL 120
SLLQIQMRDL EGYRETRYQL LQLRPTQRAS WIGYAIAYHL LKDYDMALKL LEEFRQTQQV 180
PPNKIDYEYS ELILYQNQVM READLLQESL EHIEMYEKQI CDKLLVEEIK GEILLKLGRL 240
KEASEVFKNL IDRNAENWCY YEGLEKALQI STLEERLQIY EEISKQHPKA ITPRRLPLTL 300
VPGERFRELM DKFLRVNFSK GCPPLFTTLK SLYYNTEKVS IIQELVTNYE ASLKTCDFFS 360
PYENGEKEPP TTLLWVQYFL AQHFDKLGQY SLALDYINAA IASTPTLIEL FYMKAKIYKH 420
IGNLKEAAKW MDEAQSLDTA DRFINSKCAK YMLRANMIKE AEEMCSKFTR EGTSAMENLN 480
EMQCMWFQTE CISAYQRLGR YGDALKKCHE VERHFFEITD DQFDFHTYCM RKMTLRAYVD 540
LLRLEDILRR HAFYFKAARS AIEIYLKLYD NPLTNESKQQ EINSENLSAK ELKKMLSKQR 600
RAQKKAKLEE ERKHAERERQ QKNQKKKRDE EEEEASGLKE ELIPEKLERV ENPLEEAVKF 660
LIPLKNLVAD NIDTHLLAFE IYFRKGKFLL MLQSVKRAFA INSNNPWLHE CLIRFSKSVS 720
NHSNLPDIVS KVLSQEMQKI FVKKDLESFN EDFLKRNATS LQHLLSGAKM MYFLDKSRQE 780
KAIAIATRLD ETIKDKDVKT LIKVSEALLD GSFGNCSSQY EEYRMACHNL LPFTSAFLPA 840
VNEVDNPNVA LNHTANYDVL ANEI 864 
Gene Ontology
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0005667; C:transcription factor complex; ISS:UniProtKB.
 GO:0006474; P:N-terminal protein amino acid acetylation; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB. 
Interpro
 IPR021183; NatA_aux_su.
 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 
Pfam
 PF12569; NARP1 
SMART
 SM00028; TPR 
PROSITE
 PS50005; TPR
 PS50293; TPR_REGION 
PRINTS