| Tag | Content |
|---|
| CPLM ID | CPLM-013260 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium-coupled monocarboxylate transporter 2 |
Protein Synonyms/Alias | Electroneutral sodium monocarboxylate cotransporter; Low-affinity sodium-lactate cotransporter; Solute carrier family 5 member 12 |
Gene Name | Slc5a12 |
Gene Synonyms/Alias | Smct2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 591 | SGLQNGLKQDTLAQI | ubiquitination | [1] | | 604 | QIPGYNPKEKSYSNS | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate. |
Sequence Annotation | CARBOHYD 219 219 N-linked (GlcNAc...) (Potential).
CARBOHYD 480 480 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Glycoprotein; Ion transport; Membrane; Reference proteome; Sodium; Sodium transport; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 619 AA |
Protein Sequence | MRVKNFEAWD YVVFAGLFVI SSGIGVFFAI KERKKTTSRE FLVGGRQMSF GPVALSLTAS 60
FMSAVTVLGT PAEVYRFGAS FFLFLISYVF VVFFTSELFL PVFYRSGITS TYEYLQLRFN 120
KPVRYAATII YIVQTILYTG VVVYAPALAL NQVTGFNLWA SVFATGIVCT FYCSLGGLKA 180
VVWTDAFQMV VMIVGFLTVL IQGSNHVGGF NNVLEKAGNG SRLHIVDFDV DPLRRHTFWT 240
ITIGGTFTWL GVYGVNQSTI QRCISCKTEK HAKLALYFNL LGLWIIVACA VFSGLIMYSH 300
FKDCDPWTSG VISAPDQLMP YFVMEIFATM PGLPGLFVAC AFSGTLSTVA ASINALATVT 360
FEDFVKSCFP HLSDKLSTWI SKGLCILFGI MCTSMAVVAS LMGSVVQAAL SIHGMCGGPM 420
LGLFTLGLVF PFVNWKGALG GLLTGITLSF WVAIGSFIYP APESKTLPLP LSTEHCVELN 480
ITTTVAPQIS SRPVLADTWY SLSYLYFSAV GCLGCIAAGI IISFLTGKQR GKDIDPLLIR 540
PVCNLFCFWS KKYKTLCWCG VQHDRETEQD YLDSGSAWKQ GVESGLQNGL KQDTLAQIPG 600
YNPKEKSYSN SVPEKTTYF 619 |
Gene Ontology | GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell. GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. GO:0015293; F:symporter activity; IEA:UniProtKB-KW. GO:0006814; P:sodium ion transport; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |