UniProt Accession

 STMN1_HUMAN; P16949; A2A2D1; B2R4E7; B7Z8N4; D3DPJ5 

Genbank Protein ID

 J04991; M31303; X53305; Z11566; X94912; AK303692; AK311801; AL033528; CH471059; CH471059; CH471059; CH471059; CH471059; CH471059; CH471059; BC082228 

Genbank Nucleotide ID

 AAA59980.1; AAA59971.1; CAA37391.1; CAA77660.1; CAA64398.1; BAH14020.1; BAG34744.1; CAC16020.1; EAX07854.1; EAX07855.1; EAX07856.1; EAX07857.1; EAX07858.1; EAX07859.1; EAX07860.1; AAH82228.1 

Protein Name

 Stathmin 

Protein Synonyms/Alias

 Leukemia-associated phosphoprotein p18; Metablastin; Oncoprotein 18; Op18; Phosphoprotein p19; pp19; Prosolin; Protein Pr22; pp17 

Gene Name

 STMN1 

Gene Synonyms/Alias

 C1orf215; LAP18; OP18 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
9	ASSDIQVKELEKRAS	ubiquitination	[1, 2]
29	LILSPRSKESVPEFP	ubiquitination	[2, 3]
42	FPLSPPKKKDLSLEE	ubiquitination	[2]
43	PLSPPKKKDLSLEEI	ubiquitination	[2]
52	LSLEEIQKKLEAAEE	ubiquitination	[2]
53	SLEEIQKKLEAAEER	ubiquitination	[2]
70	SHEAEVLKQLAEKRE	ubiquitination	[1, 2]
80	AEKREHEKEVLQKAI	ubiquitination	[2]
85	HEKEVLQKAIEENNN	ubiquitination	[2]
100	FSKMAEEKLTHKMEA	ubiquitination	[1, 2]
119	REAQMAAKLERLREK	ubiquitination	[1, 2, 3]

Reference

 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Involved in the regulation of the microtubule (MT) filament system by destabilizing microtubules. Prevents assembly and promotes disassembly of microtubules. Phosphorylation at Ser- 16 may be required for axon formation during neurogenesis. Involved in the control of the learned and innate fear (By similarity). 

Sequence Annotation

 DOMAIN 4 145 SLD.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 9 9 N6-acetyllysine.
 MOD_RES 16 16 Phosphoserine.
 MOD_RES 25 25 Phosphoserine; by CDK1, MAPK1 and MAPK3.
 MOD_RES 31 31 Phosphoserine.
 MOD_RES 38 38 Phosphoserine; by CDK1, MAPK1 and MAPK3.
 MOD_RES 46 46 Phosphoserine (By similarity).
 MOD_RES 63 63 Phosphoserine; by PKA.
 MOD_RES 95 95 N6-acetyllysine.
 MOD_RES 100 100 N6-acetyllysine.
 MOD_RES 119 119 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Direct protein sequencing; Microtubule; Neurogenesis; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 149 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005622; C:intracellular; IDA:LIFEdb.
 GO:0016020; C:membrane; IEA:Compara.
 GO:0005874; C:microtubule; IEA:UniProtKB-KW.
 GO:0004871; F:signal transducer activity; TAS:ProtInc.
 GO:0015631; F:tubulin binding; IDA:MGI.
 GO:0007409; P:axonogenesis; IEA:Compara.
 GO:0035556; P:intracellular signal transduction; TAS:ProtInc.
 GO:0007019; P:microtubule depolymerization; IDA:MGI.
 GO:0007052; P:mitotic spindle organization; IDA:MGI.
 GO:0031115; P:negative regulation of microtubule polymerization; IEA:Compara.
 GO:0051272; P:positive regulation of cellular component movement; IEA:Compara.
 GO:0009615; P:response to virus; IEP:UniProtKB. 

Interpro

 IPR000956; Stathmin_fam. 

Pfam

 PF00836; Stathmin 

SMART

  

PROSITE

 PS00563; STATHMIN_1
 PS01041; STATHMIN_2
 PS51663; STATHMIN_3 

PRINTS

 PR00345; STATHMIN.